Exhausted CD8 T cells do not upregulate CD25 expression following IL-12, IL-18, and/or IL-21 exposure.
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Representative flow cytometry plots show the expression of CD25 by gated CD8 T cells following acute (B6 Arm), protracted (B6 cl13), and chronic (CD4-/- cl13) LCMV infections in response to a 5.5 hr incubation with or without IL-12, IL-18, and IL-21 in the absence of BFA.
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Exhausted CD8 T cells do not upregulate CD25 expression following IL-12, IL-18, and/or IL-21 exposure.
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Representative flow cytometry plots show the expression of CD25 by gated CD8 T cells following acute (B6 Arm), protracted (B6 cl13), and chronic (CD4-/- cl13) LCMV infections in response to a 5.5 hr incubation with or without IL-12, IL-18, and IL-21 in the absence of BFA.
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TGF-β enhances the effect of IL-21 on the development of IL-21-producing CD4+ T cells.
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Naïve CD4+ T cells from CBMCs were stimulated for 3 days with immobilized anti-CD3 and anti-CD28 mAbs (neutral condition) in the presence or absence of IL-21, TGF-β or IL-21 plus TGF-β.
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The CD4+ T cell computational model predicts modulation of differentiation and maintenance by IL-21 in silico.
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Sensitivity analysis of IL-21 over Th1- and Th17-related molecules showing positive or negative correlation to IL-21.
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The effect of IL-21 and CD40L exposure on MEC1 and MEC2 cells.
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Expression of EBNA-2 and LMP-1 in IL-21 treated cells .
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