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Mouse SR-BI Recombinant

SR-BI

accession:  Q61009
   Size A     10ug   $ 160
   Size B      50ug  $480
   Size C      200ug  $ 1950
Domain  : 
Gene  :  SR-BI
Catalog no. :  RKQ61009

 

Source:
Optimized DNA sequence  encoding I extracellular domain of Mouse Scavenger Receptor Class B Type I (SR-BI) including a C-terminal His tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant Mouse Scavenger Receptor Class B Type I (SRB1) is a  protein consisting of 420 amino acid residue subunits,  due to glycosylation migrates as an approximately 80kDa protein on SDS-PAGE.


 
Purity:
>90%, as determined by SDS-PAGE and HPLC
 

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Mouse SR-BI(SCARB1) is lyophilized from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Storage:
Recombinant SR-BI can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

Scavenger Receptor Class B Type I

Scavenger receptor class B, type I (SR-BI), is a high- affinity receptor for high- density lipoprotein (HDL) cholesterol, and it also binds low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, and phospholipids. The classical function of SR-BI is to mediate the selective uptake of HDL cholesterol by cells, primarily in the form of cholesteryl esters. SR-BI also mediates the bidirectional flux of unesterified cholesterol and phospholipids between lipoproteins and cell plasma membranes (PMs).1 The binding of HDL to hepatic SR-BI and the selective uptake of cholesterol that ensues underlie the delivery of extrahepatic cholesterol to the liver in the process known as reverse cholesterol transport (RCT). SR-BI and the related receptor CD36 share a hairpin-like membrane topology, with the midportion of the protein that resides extracellularly anchored to the PM by 2 transmembrane domains adjacent to short N-terminal and C-terminal cytoplasmic domains.

Related Publications:
hypervariable region 1 deletion and required adaptive envelope mutations confer decreased dependency on Scavenger Receptor Class B Type I and low-density lipoprotein receptor for hepatitis c virus
J. Vi
abstract 16551: the Scavenger Receptor Class B Type I (sr-bi) chaperones the syndecan-1 heparan sulfate proteoglycan to the surface of hepatocytes: novel role in the clearance of atherogenic postprandial remnant lipoproteins
Ci
abstract 18570: intronic scarb1 (Scavenger Receptor Class B Type I, sr-bi) rs10846744 variant mediates functional effect by enhancer activity
Ci
different requirements for Scavenger Receptor Class B Type I in hepatitis c virus cell-free versus cell-to-cell transmission
J. Vi
noncanonical role of the pdz4 domain of the adaptor protein pdzk1 in the regulation of the hepatic high density lipoprotein receptor scavenger receptor class b, type i (sr-bi)
J. B




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by species:
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mouse
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Antibodies:
Purified Polyclonal
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