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Human Carnosinase Recombinant


accession:  Q96KN2
   Size A     10ug   $ 160
   Size B      50ug  $550
   Size C      200ug  $ 1950
Domain  : 
Gene  :  CN-1
Catalog no. :  RKQ96KN2



Optimized DNA sequence encoding Human Carnosinase -CNDP1 (SER28 - HIS508) mature chain including a C-terminal His tag was expressed in HEK293 cells.

Molecular weight:

Recombinant Human Carnosinase (CN1) is a protein consisting of 488 amino acid residue subunits,due to glycosylation migrates as an approximately as 69kDa band protein on reduced SDS-PAGE.

>95%, as determined by SDS-PAGE and HPLC
Biological Activity:
The activity was measured by the ability to cleave carnosine, the activity was calculated to be >250 pmol/min/g
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Recombinant human Carnosinase (CNDP1) is lyophilized  from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Recombinant Human Carnosinase (CNDP1)can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.



Serum carnosinase, a dipeptidase belonging to the M20 metalloprotease family, is the rate-limiting enzyme for the hydrolysis of carnosine into β-alanine and histidine. Carnosine is an antioxidant, inhibits nonenzymatic glycosylation , prevents high glucose induced extracellular matrix accumulation, and prevents cross-linking of proteins caused by reactive aldehydes

Related Publications:
does low serum Carnosinase activity favor high-intensity exercise capacity?
J Appl Physiol, Mar 2014; 116: 553 - 559.
low plasma Carnosinase activity promotes carnosinemia after carnosine ingestion in humans
Am J Physiol Renal Physiol, Jun 2012; 302: F1537 - F1544.
n-glycosylation of Carnosinase influences protein secretion and enzyme activity: implications for hyperglycemia
Diabetes, Aug 2010; 59: 1984 - 1990.
structural basis for substrate recognition and hydrolysis by mouse Carnosinase cn2
J. Biol. Chem., Oct 2008; 283: 27289 - 27299.
exclusion of polymorphisms in Carnosinase genes (cndp1 and cndp2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies
Diabetes, Sep 2008; 57: 2547 - 2551.

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Purified Polyclonal
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product_icon_8.jpg Mouse Carnosinase Recombinant
product_icon_8.jpg Human Carnosinase Recombinant
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