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Human GITR Ligand Recombinant, Fc

GITRL

accession:  P55058
   Size A     10ug   $ 160
   Size B      50ug  $550
   Size C      200ug  $ 1950
Domain  : 
Gene  :  GITRL
Catalog no. :  RKQ9UNG2

 

Source:

Optimized DNA sequence encoding Human GITR Ligand -GITRL (GLN50 - SER177 ) mature chain including a C-terminal His tag was expressed in HEK293 cells.


 
Molecular weight:

Recombinant Human GITR Ligand(TNFSF18) is a homodimer protein consisting of 2x350 amino acid residue subunits,due to glycosylation migrates as an approximately as 46kDa band protein on reduced SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant human GITR Ligand (GITRL) is lyophilized  from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
Recombinant Human GITR Ligand can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

GITR Ligand

The pathway between glucocorticoid-induced tumor necrosis factor (TNF) receptor family-related protein (GITR) and GITR ligand (GITRL) have been shown to control the function of regulatory T cells (Treg). GITRL is a type II transmembrane protein belonging to the TNF superfamily, and cell surface expression has been observed on B cells, macrophages, and dendritic cells.

Related Publications:
GITR Ligand provided by thrombopoietic cells inhibits nk cell antitumor activity
J. Immunol., Jul 2012; 189: 154 - 160.
a novel il-10–independent regulatory role for b cells in suppressing autoimmunity by maintenance of regulatory t cells via GITR Ligand
J. Immunol., Apr 2012; 188: 3188 - 3198.
th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, gitr–GITR Ligand costimulation in vivo
J. Immunol., Aug 2011; 187: 1411 - 1420.
GITR Ligand–mediated local expansion of regulatory t cells and immune privilege of corneal allografts
Invest. Ophthalmol. Vis. Sci., Dec 2010; 51: 6556 - 6565.
pseudoexpression of glucocorticoid-induced tnf-related (gitr) ligand upon coating of cancer cells by platelets impairs nk cell anti-tumor reactivity
Blood (ASH Annual Meeting Abstracts), Nov 2010; 116: 3193.




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