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Human Anterior gradient-2 Recombinant

AGR2

accession:  O95994
   Size A     10ug   $ 160
   Size B      50ug  $680
   Size C      500ug  $ 3500
Domain  : 
Gene  :  VTCN1
Catalog no. :  RKO95994

 

Source:

Optimized DNA sequence  encoding mature chain of human anterior gradient-2, AGR2 (ARG21 - LEU175 ) , including a C-terminal His tag was expressed in HEK293 cells.


 
Molecular weight:

Recombinant Human AGR2 is a protein consisting of 162 amino acid residue subunits,due to glycosylation migrates as an approximately as 50kDa band protein on reduced SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC
 

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant human AGR-2 is lyophilized  from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
Recombinant AGR2 can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

AGR2

Anterior Gradient Homolog 2 (AGR2) encodes a 17-kDa protein that is highly conserved in vertebrates. AGR2 was first described in Xenopus laevis where its expression is responsible for the development of a glandular organ called the cement gland . AGR2 is also expressed by secretory cells in the normal murine intestine (11). In humans, enhanced AGR2 expression was first described in breast cancer, which was followed by similar observations in most human adenocarcinomas, including those derived from the esophagus, pancreas, lung, ovary, and prostate

Related Publications:
trif-mediated tlr3 and tlr4 signaling is negatively regulated by ADAM15
J. Immunol., Mar 2013; 190: 2217 - 2228.
ADAM15 deficiency attenuates pulmonary hyperpermeability and acute lung injury in lipopolysaccharide-treated mice
Am J Physiol Lung Cell Mol Physiol, Feb 2013; 304: L135 - L142.
ADAM15 protein amplifies focal adhesion kinase phosphorylation under genotoxic stress conditions
J. Biol. Chem., Jun 2012; 287: 21214 - 21223.
exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes
FASEB J, Jul 2012; 26: 3084 - 3095.
a multi-pronged gene expression approach identifies ADAM15 (metargidin) as a potential therapeutic target for amd
Invest. Ophthalmol. Vis. Sci., Mar 2012; 53: 3194.




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