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Human CD69 Recombinant

CD69

accession:  Q07108
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  : 
Gene  :  CD69
Catalog no. :  RKQ07108

 

Source:

Optimized DNA sequence  encoding extracellular domain of Human CD69 (SER62 - LYS199) including a C-terminal His tag was expressed in HEK293 cells.


 
Molecular weight:

Recombinant Human CD69 is a protein consisting of 137 amino acid residue subunits,due to glycosylation migrates as an approximately as 23kDa band protein on reduced SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC
 

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant human CD69 is lyophilized  from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
Recombinant CD69 can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CD69

CD69 is a type II C-type lectin involved in lymphocyte migration and cytokine secretion. CD69 is a disulfide–linked homodimer and a member of the natural killer receptor family. Its genes are located in a conserved genomic region known as the natural killer gene cluster on mouse chromosome 6 and human chromosome 12.CD69 expression represents one of the earliest available indicators of leukocyte activation and its rapid induction occurs through transcriptional activation. In contrast to other members of the NK C-type lectin cluster, CD69 has not been established to have a role in NK cell recognition of target cells. In transgenic overexpression studies, CD69 inhibited T cell egress from the thymus

Related Publications:
non-traditional cd4+ cd25–CD69+ regulatory t cells is correlated to leukemia relapse after allogeneic hematopoietic stem cell transplantation
Blood, Nov 2013; 122: 3259.
differential effect of CD69 targeting on bystander and antigen-specific t cell proliferation
J. Leukoc. Biol., Jul 2012; 92: 145 - 158.
type ii membrane protein CD69 regulates the formation of resting t-helper memory
PNAS, May 2012; 109: 7409 - 7414.
CD69 regulates type i ifn-induced tolerogenic signals to mucosal cd4 t cells that attenuate their colitogenic potential
J. Immunol., Feb 2012; 188: 2001 - 2013.
activated CD69+ t cells foster immune privilege by regulating ido expression in tumor-associated macrophages
J. Immunol., Feb 2012; 188: 1117 - 1124.




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Antibodies:
Purified Polyclonal
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product_icon_8.jpg Human CD69 Recombinant
 
 
 
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