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Human ADAM15 Recombinant


accession:  Q13444
   Size A     5ug   $ 160
   Size B      20ug  $480
   Size C      100ug  $ 1950
Domain  : 
Gene  :  ADAM15
Catalog no. :  RKQ13444



Optimized DNA sequence  encoding extracellular domain of human Disintegrin and metalloproteinase 15- ADAM15 (ASP207 - THR696) including a C-terminal His tag was expressed in HEK293 cells.

Molecular weight:

Recombinant human ADAM15 (MDC15) is a protein consisting of 497 amino acid residue subunits,due to glycosylation migrates as an approximately as 70kDa  band protein on reduced SDS-PAGE.

>95%, as determined by SDS-PAGE and HPLC
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Recombinant Human ADAM15(MDC-15) is lyophilized  from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Recombinant ADAM15 can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.



ADAM15 is unique because of the presence of an Arginine- Glycine-Aspartic acid (RGD) motif in its disintegrin domain that binds αvβ3 and α5β1 integrins.Furthermore, ADAM15 is among the several members in the ADAM family exhibiting sheddase activity, conferred by zinc- binding protease active sites in their metalloprotease domain, enabling cleavage of cell surface proteins. MDC-15 (metargidin) (13, 14) is the only known MDC that has an RGD sequence in its disintegrin-like domain. MDC-15 is widely expressed in various tissues and cells, including human umbilical vein endothelial cells and smooth muscle cells

Related Publications:
trif-mediated tlr3 and tlr4 signaling is negatively regulated by ADAM15
J. Immunol., Mar 2013; 190: 2217 - 2228.
ADAM15 deficiency attenuates pulmonary hyperpermeability and acute lung injury in lipopolysaccharide-treated mice
Am J Physiol Lung Cell Mol Physiol, Feb 2013; 304: L135 - L142.
ADAM15 protein amplifies focal adhesion kinase phosphorylation under genotoxic stress conditions
J. Biol. Chem., Jun 2012; 287: 21214 - 21223.
exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes
FASEB J, Jul 2012; 26: 3084 - 3095.
a multi-pronged gene expression approach identifies ADAM15 (metargidin) as a potential therapeutic target for amd
Invest. Ophthalmol. Vis. Sci., Mar 2012; 53: 3194.

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product_icon_8.jpg Mouse ADAM15 Recombinant
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