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Human Cathepsin S Recombinant

CTSS

accession:  P25774
   Size A     10ug   $ 160
   Size B      50ug  $680
   Size C      200ug  $ 1950
Domain  : 
Gene  :  CTSS
Catalog no. :  RKP25774

 

Source:

Optimized DNA sequence  encoding mature chain of human Cathepsin S -CatS (GLN17 - ILE331) including a C-terminal His tag was expressed in HEK293 cells.


 
Molecular weight:

Recombinant human Cathepsin S (CTSS) is a protein consisting of 329 amino acid residue subunits,due to glycosylation migrates as an approximately as 26kDa (mature chain) and 37kDa (propeptide) band protein on reduced SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC
 
Biological activity:
The activity was tested by the ability to cleave a flourogenic substrate , the measured activity is 300 pmole/ug/min
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Human Cathepsin S is lyophilized  from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
Recombinant Cathepsin S can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

Cathepsin S

Cathepsin S, unlike the ubiquitous cathepsin B and cathepsin L, exhibits a restricted tissue expression. It is found predominantly in lymphatic tissue, macrophages, and other professional antigen- presenting cells; mediating key steps in antigen presentation through cleavage of the invariant chain.

Related Publications:
Cathepsin S contributes to macrophage migration via degradation of elastic fibre integrity to facilitate vein graft neointimal hyperplasia
Cardiovas
peripheral role of Cathepsin S in th1 cell-dependent transition of nerve injury-induced acute pain to a chronic pain state
J. Neuros
Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because Cathepsin S is essential for mhc class ii-mediated cd4 t cell and b cell priming
Ann Rheum Dis
abstract c161: fsn0503h antibody-mediated blockade of Cathepsin S as potential therapeutic strategy for the treatment of solid tumors.
Mol. Cancer Ther., Nov 2013; 12: C161.
Cathepsin S-mediated fibroblast trans-differentiation contributes to left ventricular remodelling after myocardial infarction
Cardiovas




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