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Human BACE1 Recombinant

BACE1

accession:  P56817
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  : 
Gene  :  BACE1
Catalog no. :  RKP56817

 

Source:

Optimized DNA sequence  encoding  extracellular domain of Human beta Site Amyloid Precursor Protein- BACE1 (THR22-THR457 ) including a C-terminal His tag was expressed in HEK293 cells.


 
Molecular weight:

Recombinant human BACE1 is a protein consisting of 440 amino acid residue subunits,due to glycosylation migrates as an approximately 60kDa protein on reduced SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC
 
Biological Activity:
The activity was tested by the ability to digest a fluorogenic substrate and measuered to be 4 pmoles/min/ug
 
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Human BACE1 is lyophilized  from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Storage:
Recombinant BACE1 can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

BACE1

β-Site amyloid precursor protein-cleaving enzyme (BACE1) is a membrane- tethered member of the aspartyl proteases that has been identified as β- secretase. BACE1 is targeted through the secretory pathway to the plasma membrane and then is internalized to endosomes. Sorting of membrane proteins to the endosomes and lysosomes is regulated by the interaction of signals present in their carboxyl- terminal fragment with specific trafficking molecules. The BACE1 carboxyl-terminal fragment contains a di-leucine sorting signal and a ubiquitination site at Lys- 501

Related Publications:
associations of genetic polymorphisms in the Renin-angiotensin system with central aortic and ambulatory blood pressure in type 2 diabetic patients
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a study on the polymorphisms of the Renin–angiotensin system pathway genes for their effect on blood pressure levels in males from algeria
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cardiac remodeling during and after Renin–angiotensin system stimulation in cyp1a1-ren2 transgenic rats
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maternal hyperthyroidism alters the pattern of expression of cardiac Renin-angiotensin system components in rat offspring
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Antibodies:
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