Optimized DNA sequence encoding extracellular domain of Human CXCR4 MET1 -SER46) including a N-terminal IgG1 Fc tag was expressed in HEK293 cells.
Recombinant human CXCR4 is a protein consisting of 390 amino acid residue subunits,due to glycosylation migrates as an approximately 45kDa protein on reduced SDS-PAGE.
>95%, as determined by SDS-PAGE and HPLC
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).
Recombinant Human CXCR4 is lyophilized from 0.2 μm filtered PBS solution, pH7.2 , 5% Trehalose.
Recombinant CXCR4 can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.
Avoid repeated freeze/thaw cycles.
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.
The CXCR4 chemokine receptor
is a seven transmembrane G-
protein coupled receptor
with multiple critical
functions in both the normal
and pathological states
having a sole natural ligand
Although most members of
chemokine have been
inflammatory mediators, SDF-
1/PBSF and CXCR4 have been
shown to be responsible for
B lymphopoiesis and bone
marrow myelopoiesis during
embryogenesis , as well as
,vascular formation ,
1.61 t-cells expressing tlr4 and CXCR4 are associated with an ra diagnostic in early inflammatory arthritis
Ann Rheum Dis,
A26 - A27.
β-arrestin1 and distinct CXCR4 structures are required for stromal derived factor-1 to downregulate CXCR4 cell-surface levels in neuroblastoma
542 - 552.
somatic mutations in myd88 and CXCR4 are determinants of clinical presentation and overall survival in waldenstrom's macroglobulinemia
a phase 1 clinical trial of long-term, low-dose treatment of whim syndrome with the CXCR4 antagonist plerixafor
galectin-1 upregulates CXCR4 to promote tumor progression and poor outcome in kidney cancer
J. Am. Soc. Nephrol.,