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Human CXCR4 Recombinant

CXCR4

accession:  P61073
   Size A     5ug   $ 160
   Size B      20ug  $480
   Size C      100ug  $ 1950
Domain  : 
Gene  :  CXCR4
Catalog no. :  RKP61073

 

Source:

Optimized DNA sequence  encoding  extracellular domain of Human CXCR4 MET1 -SER46) including a N-terminal IgG1 Fc tag was expressed in HEK293 cells.


 
Molecular weight:

Recombinant human CXCR4 is a protein consisting of 390 amino acid residue subunits,due to glycosylation migrates as an approximately 45kDa protein on reduced SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC
 
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Human CXCR4 is lyophilized  from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Storage:
Recombinant CXCR4 can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CXCR4

The CXCR4 chemokine receptor is a seven transmembrane G- protein coupled receptor with multiple critical functions in both the normal and pathological states having a sole natural ligand (CXCL12). Although most members of chemokine have been designated inducible inflammatory mediators, SDF- 1/PBSF and CXCR4 have been shown to be responsible for B lymphopoiesis and bone marrow myelopoiesis during embryogenesis , as well as embryonic viability ,vascular formation , cardiogenesis and neurogenesis

Related Publications:
1.61 t-cells expressing tlr4 and CXCR4 are associated with an ra diagnostic in early inflammatory arthritis
Ann Rheum Dis, Mar 2014; 73: A26 - A27.
β-arrestin1 and distinct CXCR4 structures are required for stromal derived factor-1 to downregulate CXCR4 cell-surface levels in neuroblastoma
Mol. Pharmacol., Feb 2014; 85: 542 - 552.
somatic mutations in myd88 and CXCR4 are determinants of clinical presentation and overall survival in waldenstrom's macroglobulinemia
Blood, Feb 2014; 10.1182/blood-2014-01-550905.
a phase 1 clinical trial of long-term, low-dose treatment of whim syndrome with the CXCR4 antagonist plerixafor
Blood, Feb 2014; 10.1182/blood-2013-09-527226.
galectin-1 upregulates CXCR4 to promote tumor progression and poor outcome in kidney cancer
J. Am. Soc. Nephrol., Feb 2014; 10.1681/ASN.2013070773.




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Antibodies:
Purified Polyclonal
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product_icon_8.jpg Human CXCR4 Recombinant
 
 
 
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