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Human Angiopoietin-2 Recombinant

ANG-2

accession:  O15123
   Size A     20ug   $ 160
   Size B      100ug  $550
   Size C      500ug  $ 2150
Domain  : 
Gene  :  Angiopoietin-2
Catalog no. :  RKO15123

 

Source:

Optimized DNA sequence  encoding  extracellular domain of Human Angiopoietin-2 including a C-terminal His tag was expressed in HEK293 cells. 


 
Molecular weight:

Recombinant Angpt2 is a  protein consisting of 490 amino acid residue subunits,  due to glycosylation migrates as an approximately 70kDa protein on SDS-PAGE.


 
Purity:
>97%, as determined by SDS-PAGE and HPLC
 
Biological Activity:
The activity was tested by the ability of immobilized recombinant Human Tie2 to bind biotinylated recombinant human Angiopoietin-2 in ELISA

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Human Angiopoietin-2  is lyophilized from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Storage:
Recombinant Angiopoietin-2 can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

Angiopoietin-2

Angiopoietin-2 (Ang2)2 is a 70-kDa secreted ligand whose increased expression has been implicated in a range of diseases, including cancer, sepsis, and acute respiratory distress syndrome. The primary receptor for Ang2 is the transmembrane tyrosine kinase Tie2 (3) that is expressed mainly on vascular endothelial cells and myeloid cells (1, 4). Ang2 plays an important role in vascular remodeling during development, but in adult tissues, Ang2 concentrations are usually low. An increase in Ang2 levels in disease allows the molecule to compete for binding to a common interface on Tie2 with the related agonist Ang1.

Related Publications:
Angiopoietin-2–induced arterial stiffness in ckd
J. Am. Soc. Nephrol., Feb 2014; 10.1681/ASN.2013050542.
endothelial cell-derived Angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat
Science, Jan 2014; 343: 416 - 419.
Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (pi3k)/akt/endothelial nitric oxide synthase (enos) and syndecan-4/syntenin pathways
J. Biol. Chem., Jan 2014; 289: 510 - 519.
thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through Angiopoietin-2 upregulation
Circ. Res., Dec 2013; 113: 1331 - 1344.
circulating Angiopoietin-2, its soluble receptor tie-2, and mortality in the general population
Eur J Heart Fail, Dec 2013; 15: 1327 - 1334.




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Antibodies:
Purified Polyclonal
Related Products:
product_icon_8.jpg Human Angiopoietin-2 Recombinant, Biotinylated
product_icon_8.jpg Human Angiopoietin-2 Recombinant
 
 
 
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