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Human CD3δ Recombinant

CD3

accession:  P04234
   Size A     20ug   $ 160
   Size B      100ug  $680
   Size C      500ug  $ 2750
Domain  : 
Gene  :  CD3d
Catalog no. :  RKP04234

 

Source:
Optimized DNA sequence  encoding  extracellular domain of Human CD3δ including a C-terminal His tag, were expressed in HEK293 cells.

 
Molecular weight:

Recombinant CD3δ  is a  protein consisting of Phe22-Ala125 amino acid residue subunits,  due to glycosylation migrates as an approximately 18-25kDa protein on SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC

 
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Human CD3δ  is lyophilized from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Storage:
Recombinant CD3 heterodimer can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CD3 delta

he preT-cell receptor (TCR) and the αβTCR are multimeric protein complexes expressed on the surface of developing T cells at different stages of their ontogeny in the thymus. The pre-TCR complex consists of a disulfide- linked heterodimer of an invariant pre-Tα (pTα) and a variable TCRβ chain noncovalently associated with the CD3γ, δ, ϵ, and ζ polypeptides. The overall structure and functioning of the pre-TCR and TCR complexes in mice and humans are quite similar. Despite this similarity, ablation of the highly related CD3δ and CD3γ subunits has markedly different effects in mice and humans.

Related Publications:
the feature of cd3, cd3 and cd3 gene expression in benzene-exposed and benzene- poisoned workers
Blood (ASH Annual Meeting Abstracts), Nov 2011; 118: 4929.
different composition of the human and the mouse t cell receptor explains different phenotypes of cd3 and cd3 immunodeficiencies
J. Exp. Med., Oct 2007; 204: 2537 - 2544.
a membrane-proximal tetracysteine motif contributes to assembly of cd3 and cd3 dimers with the t cell receptor
J. Biol. Chem., Dec 2006; 281: 36977 - 36984.
overlapping functions of human cd3 and mouse cd3 in t-cell development revealed in a humanized cd3-deficient mouse
Blood, Nov 2006; 108: 3420 - 3427.
biochemical evidence for the presence of a single cd3 and cd3 chain in the surface t cell receptor/cd3 complex
J. Biol. Chem., Dec 2004; 279: 51068 - 51074.




by class:
Cytokines
Chemokines
Growth factors
CD markers
Viral Antigens
Other
by species:
Human
mouse
Rat
Antibodies:
Purified Polyclonal
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