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Human CTLA4 (CD152) Recombinant

CTLA4

accession:  P16410
   Size A     50ug   $ 160
   Size B      200ug  $480
   Size C      1000ug  $ 1950
Domain  :  Extracellular
Gene  :  CTLA4
Catalog no. :  RKP16410
Source:
DNA sequence encoding extracellular domain of Human CTLA4  to a C-terminal polyHis tag was expressed in HEK cells.

 
Molecular weight:

Recombinant Human CTLA4 (CD152)  is a monomer consisting of 137 amino acid residue , and migrates as an approximately 25 kDa protein under reducing conditions in SDS-PAGE.

 
Purity:
>95%, as determined by SDS-PAGE

 
Biological Activity:
The activity was tested by immobilized recombinant CTLA4 (10ug/ml) ability to bind recombinant human B7-1 in functional ELISA.  The ED50 was calculated to be  10ng/ml.

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Human CTLA4 was lyophilized from a 0.2 μm filtered PBS  pH 7.4.

 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
The lyophilized protein is stable for at least 2 years from date of receipt at -20° C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:
This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

 

CTLA4

Cytotoxic T lymphocyte– associated antigen 4 (CTLA4) is an inhibitory receptor expressed on T-cell surface that is induced by T-cell activation to negatively regulate excessive activation of T cells.

Related Publications:
development of gaba circuitry of fast-spiking basket interneurons in the medial prefrontal cortex of ERBB4-mutant mice
J. Neurosci., Dec 2013; 33: 19724 - 19733.
regulation of spine formation by ERBB4 in pv-positive interneurons
J. Neurosci., Dec 2013; 33: 19295 - 19303.
ERBB4 reduces synaptic gabaa currents independent of its receptor tyrosine kinase activity
PNAS, Nov 2013; 110: 19603 - 19608.
cdk5 phosphorylation of ERBB4 is required for tangential migration of cortical interneurons
Cereb Cortex, Oct 2013; 10.1093/cercor/bht290.
neuregulin-1/ERBB4 signaling regulates kv4.2-mediated transient outward k+ current through the akt/mtor pathway
Am J Physiol Cell Physiol, Jul 2013; 305: C197 - C206.




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