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Human HER3 (ERBB3) Recombinant , Biotinylated

HER3

accession:  P21860
   Size A     10ug   $ 340
   Size B      25ug  $590
   Size C      100ug  $ 1950
Domain  :  Extracellular
Gene  :  ERBB3
Catalog no. :  RPB21860
Source:
DNA sequence encoding extracellular domain of Human HER3 (ERBB3)  to a C-terminal polyHis tag was expressed in CHO cells.

 
Molecular weight:

Recombinant Human HER3/ERBB3  is a monomer consisting of 640 amino acid residue , and migrates as an approximately 75 kDa protein under reducing conditions in SDS-PAGE.

 
Purity:
>95%, as determined by SDS-PAGE

 
Applications:
ELISA,WB:  Biotinylated HER3 was designed to be used in single step detection in ELISA ,WB
 

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Human HER2 was lyophilized from a 0.2 μm filtered PBS  pH 7.4.

 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
The lyophilized protein is stable for at least 2 years from date of receipt at -20° C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:
This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

 

HER3

ErbB3 is an important regulator of tumorigenesis and is implicated in development of resistance to several currently used oncology drugs. nappropriate signaling through the EGF receptor (EGFR, ErbB) family of receptors can promote tumorigenesis and many epithelial cancers are marked by functional activation of ErbB family members. The ErbB family consists of 4 related tyrosine kinase receptors EGFR, ErbB2 (HER2/NEU), ErbB3, and ErbB4. ErbB3 is unique among these because it is deficient in tyrosine kinase activity. However, it is readily phosphorylated upon heterodimerization with ligand-activated EGFR or with ErbB2. In its fully phosphorylated state, it contains 6 binding sites for phosphoinositide 3-kinases (PI3K) and therefore constitutes one of the most potent activators of the AKT signaling pathway

Related Publications:
her2 and HER3 expression in hepatic metastases of colorectal cancer: new targets for specific treatment approaches?
ASCO Meeting Abstracts, Jan 2014; 32: 567.
potential regulators of her2 activity in her2-overexpressing gastric and gastroesophageal tumors: analysis of HER3 and heregulin expression.
ASCO Meeting Abstracts, Jan 2014; 32: 48.
neuregulin autocrine signaling promotes self-renewal of breast tumor-initiating cells by triggering her2/HER3 activation
Cancer Res., Jan 2014; 74: 341 - 352.
combination of antibody that inhibits ligand-independent HER3 dimerization and a p110α inhibitor potently blocks pi3k signaling and growth of her2+ breast cancers
Cancer Res., Oct 2013; 73: 6013 - 6023.
an antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by her2 or neuregulin
Cancer Res., Oct 2013; 73: 6024 - 6035.




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product_icon_8.jpg Human HER3 (ERBB3) Recombinant , Biotinylated
 
 
 
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