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Human HER2 (ERBB2) Recombinant , Biotinylated

HER2

accession:  P04626
   Size A     10ug   $ 340
   Size B      25ug  $590
   Size C      100ug  $ 1950
Domain  :  Extracellular
Gene  :  ERBB2
Catalog no. :  RPB04626
Source:
DNA sequence encoding extracellular domain of Human HER2 (ERBB2)  to a C-terminal polyHis tag was expressed in CHO cells.

 
Molecular weight:

Recombinant Human HER2  is a monomer consisting of 640 amino acid residue , and migrates as an approximately 75 kDa protein under reducing conditions in SDS-PAGE.

 
Purity:
>95%, as determined by SDS-PAGE

 
Applications:
ELISA,WB:  Biotinylated HER2 was designed to be used in single step detection in ELISA ,WB
 

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Human HER2 was lyophilized from a 0.2 μm filtered PBS  pH 7.4.

 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
The lyophilized protein is stable for at least 2 years from date of receipt at -20° C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:
This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

 

HER2

The epidermal growth factor receptor (EGFR) is a 170,000-kDa trans-membrane glycoprotein involved in signaling pathways affecting cellular growth, differentiation, and proliferation.1 An abnormal expression of the EGFR has been described in many human tumors and implicated in the development and prognosis of malignancies, thus representing not only a possible prognostic markers but primarily a rational molecular target for a new class of anticancer agents

Related Publications:
positron emission tomography imaging with 18f-labeled zHER2:2891 affibody for detection of HER2 expression and pharmacodynamic response to HER2-modulating therapies
Clin. Cancer Res., Feb 2014; 10.1158/1078-0432.CCR-13-2421.
managing breast cancers with low estrogen receptor and HER2 by drugging both
Clin. Cancer Res., Feb 2014; 20: 528 - 530.
muc4-mediated regulation of acute phase protein lipocalin 2 through HER2/akt/nf-b signaling in pancreatic cancer
Clin. Cancer Res., Feb 2014; 20: 688 - 700.
quantitative er and pgr assessment as predictors of benefit from lapatinib in postmenopausal women with hormone receptor–positive, HER2-negative metastatic breast cancer
Clin. Cancer Res., Feb 2014; 20: 736 - 743.
long-term treatment efficacy in primary inflammatory breast cancer by hormonal receptor- and HER2-defined subtypes
Ann. Onc., Feb 2014; 25: 384 - 391.




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Antibodies:
Purified Polyclonal
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