Optimized DNA sequence encoding extracellular domain of Human CD36 including a C-terminal His tag was expressed in HEK293 cells.
Recombinant CD36 (Fatty Acid Translocase) is a protein consisting of 420 amino acid residue subunits, due to glycosylation migrates as an approximately 80kDa protein on SDS-PAGE.
>90%, as determined by SDS-PAGE and HPLC
The activity was tested by the ability of immobilized recombinant human CD36 to bind Human RSPO1 with a linear range of 3-4000 ng/ml
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).
Recombinant Human CD36 is lyophilized from 0.2 μm filtered PBS solution, pH7.2 , 5% Trehalose.
Recombinant CD36 can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.
Avoid repeated freeze/thaw cycles.
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.
FAT/CD36 is an 88-kDa
ditopic glycosylated protein
that belongs to the class B
family of scavenger
receptors. This family also
includes scavenger receptor
class B type I (SR-BI), the
receptor for selective
cholesteryl ester uptake,
and lysosomal integral
membrane protein II (LIMP-
II) . The receptors are
expressed in microglia,
cardiac and skeletal muscle,
adipocytes, and platelets.
elicits a wide variety of
and migration of microglia
Studies utilizing a
nonmetabolizable fatty acid
analogue, BMIPP, suggest
that FAT/CD36 accounts for
50% to 80% of the total
fatty acid uptake by the
clonal variants of plasmodium falciparum exhibit a narrow range of rolling velocities to the host receptor CD36 under dynamic flow conditions
thrombospondin-1 modulates vegf signaling via CD36 by recruiting shp-1 to vegfr2 complex in microvascular endothelial cells
1822 - 1832.
pp2 and piceatannol inhibit prp106–126-induced inos activation mediated by CD36 in bv2 microglia
Acta Biochim Biophys Sin,
763 - 772.
obesity alters the gustatory perception of lipids in the mouse: plausible involvement of lingual CD36 J. Lipid Res.,
2485 - 2494.
CD36 deletion reduces vldl secretion, modulates liver prostaglandin levels and exacerbates hepatic steatosis in ob/ob mice
J. Lipid Res.,