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Human CD36 (FAT) Recombinant

CD36

accession:  P16671
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  : 
Gene  :  CD36
Catalog no. :  RKP16671

 

Source:
Optimized DNA sequence  encoding  extracellular domain of Human CD36 including a C-terminal His tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant CD36 (Fatty Acid Translocase) is a  protein consisting of 420 amino acid residue subunits,  due to glycosylation migrates as an approximately 80kDa protein on SDS-PAGE.


 
Purity:
>90%, as determined by SDS-PAGE and HPLC

 
Biological Activity:
The activity was tested by the ability of immobilized recombinant human CD36 to bind Human RSPO1  with a linear range of 3-4000 ng/ml

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Human CD36 is lyophilized from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Storage:
Recombinant CD36 can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CD36

FAT/CD36 is an 88-kDa ditopic glycosylated protein that belongs to the class B family of scavenger receptors. This family also includes scavenger receptor class B type I (SR-BI), the receptor for selective cholesteryl ester uptake, and lysosomal integral membrane protein II (LIMP- II) . The receptors are expressed in microglia, monocytes/macrophages, microvascular endothelium, cardiac and skeletal muscle, adipocytes, and platelets. The multiple ligands/receptor interaction elicits a wide variety of physiological and pathological processes, including inflammation, lipid metabolism, phagocytosis, angiogenesis, and migration of microglia Studies utilizing a nonmetabolizable fatty acid analogue, BMIPP, suggest that FAT/CD36 accounts for 50% to 80% of the total fatty acid uptake by the heart

Related Publications:
clonal variants of plasmodium falciparum exhibit a narrow range of rolling velocities to the host receptor CD36 under dynamic flow conditions
Eukaryot. Cell, Sep 2013; 10.1128/EC.00148-13.
thrombospondin-1 modulates vegf signaling via CD36 by recruiting shp-1 to vegfr2 complex in microvascular endothelial cells
Blood, Sep 2013; 122: 1822 - 1832.
pp2 and piceatannol inhibit prp106–126-induced inos activation mediated by CD36 in bv2 microglia
Acta Biochim Biophys Sin, Sep 2013; 45: 763 - 772.
obesity alters the gustatory perception of lipids in the mouse: plausible involvement of lingual CD36
J. Lipid Res., Sep 2013; 54: 2485 - 2494.
CD36 deletion reduces vldl secretion, modulates liver prostaglandin levels and exacerbates hepatic steatosis in ob/ob mice
J. Lipid Res., Aug 2013; 10.1194/jlr.M037812.




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Antibodies:
Purified Polyclonal
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