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Human CD20 Recombinant

CD20

accession:  P11836
   Size A     5ug   $ 160
   Size B      20ug  $430
   Size C      100ug  $ 1950
Domain  : 
Gene  :  MS4A1
Catalog no. :  RKP11836

Source:
Optimized DNA sequence encoding cytoplasmic domain of human CD20 including a N-terminal 6His tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant CD20 is a monomer protein consisting of 105 amino acid residue subunits,  due to glycosylation migrates as an approximately 20kDa protein on SDS-PAGE.


 
Purity:
>98%, as determined by SDS-PAGE and HPLC
 

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant CD20 is supplied as a 0.2 μm filtered PBS solution,  pH7.2 .

              
Storage:
Recombinant CD20, as supplied, can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CD20

CD20 is a signature B-cell differentiation antigen strongly expressed on the surface of mature normal as well as malignant B cells. It is also expressed, but at lower levels and with larger variance, on more immature B cells and their malignant counterparts found in B-cell precursor (BCP) acute lymphoblastic leukemia

Related Publications:
reduced t-dependent humoral immunity in CD20-deficient mice
J. Immunol., Sep 2013; 191: 3112 - 3118.
recombinant human il-15 trans-presentation by b leukemic cells from chronic lymphocytic leukemia induces autologous nk cell proliferation leading to improved anti-CD20 immunotherapy
J. Immunol., Aug 2013; 10.4049/jimmunol.1300187.
combination treatment with anti-CD20 and oral anti-cd3 prevents and reverses autoimmune diabetes
Diabetes, Aug 2013; 62: 2849 - 2858.
salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas
Blood, Aug 2013; 122: 705 - 714.
preclinical activity of the type ii CD20 antibody ga101 (obinutuzumab) compared with rituximab and ofatumumab in vitro and in xenograft models
Mol. Cancer Ther., Jul 2013; 10.1158/1535-7163.MCT-12-1182.




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Antibodies:
Purified Polyclonal
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