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Mouse 4-1BB (CD137) Recombinant

4-1BB

accession:  P20334
   Size A     20ug   $ 160
   Size B      100ug  $430
   Size C      500ug  $ 1950
Domain  : 
Gene  :  CD137
Catalog no. :  RKP20334

 

Source:
Optimized DNA sequence  encoding  Mouse 4-1BB  (CD137)  fused to a C terminal IgG1 Fc tag was expressed in CHO Cells.

 
Molecular weight:

Recombinant Mouse 4-1BB (CD137)  is a  homodimer protein consisting of two 430 amino acid residue subunits,  due to glycosylation migrates as an approximately 65kDa protein on SDS-PAGE under reducing conditions.


 
Purity:
>97%, as determined by SDS-PAGE and HPLC
 
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant mouse CD137  is lyophilized from 0.2 μm filtered PBS solution,  pH7.2 .

              
Storage:
Recombinant Mouse 4-1BB can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

4-1BB

4-1BB (CD137) is a member of the TNF receptor superfamily expressed on activated CD4 and CD8 T cells as well as on activated NK cells. The binding of 4-1BB to its TNF family ligand, 4-1BB ligand (4-1BBL) delivers a costimulatory signal to resting T cells leading to high level IL-2 production independently of CD28 signaling .

Related Publications:
pilot study of redirected autologous t cells engineered to contain anti-cd19 attached to tcr and 4-1BB signaling domains in patients with chemotherapy-resistant or -refractory cd19+ leukemia and lymphoma.
ASCO Meeting Abstracts, May 2013; 31: TPS10072.
gitr-dependent regulation of 4-1BB expression: implications for t cell memory and anti–4-1BB–induced pathology
J. Immunol., May 2013; 190: 4627 - 4639.
leukocyte-specific protein 1 links tnf receptor-associated factor 1 to survival signaling downstream of 4-1BB in t cells
J. Leukoc. Biol., May 2013; 93: 713 - 721.
systemic 4-1BB activation induces a novel t cell phenotype driven by high expression of eomesodermin
J. Exp. Med., Apr 2013; 210: 743 - 755.
a converse 4-1BB and cd40 ligand expression pattern delineates activated regulatory t cells (treg) and conventional t cells enabling direct isolation of alloantigen-reactive natural foxp3+ treg
J. Immunol., Dec 2012; 189: 5985 - 5994.




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Antibodies:
Purified Polyclonal
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