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Mouse 4-1BB Ligand (TNFSF9) Recombinant


accession:  P41274
   Size A     10ug   $ 160
   Size B      50ug  $480
   Size C      500ug  $ 3500
Domain  : 
Gene  :  TNFSF9
Catalog no. :  RKP41274


Optimized DNA sequence  encoding  Mouse 4-1BB Ligand (4-1BBL)  was expressed in HEK Cells.

Molecular weight:

Recombinant Mouse 4-1BBL  is a  protein consisting of 220 amino acid residue subunits,  due to glycosylation migrates as an approximately 25kDa protein on SDS-PAGE under reducing conditions.

>97%, as determined by SDS-PAGE and HPLC

Biological Activity:
The activity was tested by the ability of immobilized recombinant mouse 4-1BBL to bind human 4-1BB  with a linear range of  10-500 ng/ml

Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Recombinant mouse 4-1BB Ligand  is lyophilized from 0.2 μm filtered PBS solution,  pH7.2 .

Recombinant Mouse 4-1BBL can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.



4-1BB (CD137) is a member of the TNF receptor superfamily expressed on activated CD4 and CD8 T cells as well as on activated NK cells. The binding of 4-1BB to its TNF family ligand, 4-1BB ligand (4-1BBL) delivers a costimulatory signal to resting T cells leading to high level IL-2 production independently of CD28 signaling .

Related Publications:
4-1BBL reverse signaling enhances proliferation of human multiple myeloma cell line u266
Blood (ASH Annual Meeting Abstracts), Nov 2011; 118: 5074.
the combination of 4-1BBL and cd40l strongly enhances the capacity of dendritic cells to stimulate hiv-specific t cell responses
J. Leukoc. Biol., Jun 2011; 89: 989 - 999.
4-1BBL-expressing aapcs attenuate il-15-induced nk cell expansion and cytokine production in vitro but induce nk cell-mediated gvhd in vivo
Blood (ASH Annual Meeting Abstracts), Nov 2010; 116: 2536.
abstract 2416: sa-4-1BBL costimulatory ligand as an immune modulator and effective vehicle to deliver antigens into dendritic cells for the generation of robust therapeutic antitumor immune responses
Cancer Res., Apr 2010; 70: 2416.
abstract 5595: antitumor immune responses to nitroreductase/cb1954 and 4-1BBL gene therapy
Cancer Res., Apr 2010; 70: 5595.

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product_icon_8.jpg Human 4-1BB Ligand (TNFSF9) Recombinant
product_icon_8.jpg Mouse 4-1BB Ligand (TNFSF9) Recombinant
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