Cart contains    items
SEARCH

  |
  |  
  |  
  |  
  |  
  |  
 
Browse by molecule: [A]  [B]  [C]  [D]  [E]  [F]  [G]  [H]  [I]  [J]  [K]  [L]  [M]  [N]  [O]  [P]  [Q]  [R]  [S]  [T]  [U]  [V]  [W]  [X]  [Y]  [Z]  

Human L-Selectin (CD62L) Recombinant

CD62L

accession:  P14151
   Size A     50ug   $ 160
   Size B      200ug  $430
   Size C      1000ug  $ 1950
Domain  : 
Gene  :  SELL
Catalog no. :  RKP14151

 

Source:
Optimized DNA sequence  encoding  extracellular domain of Human L-Selectin including a C-terminal His tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant L-Selectin is a  protein consisting of 300 amino acid residue subunits,  due to glycosylation migrates as an approximately 60kDa protein on SDS-PAGE.


 
Purity:
>97%, as determined by SDS-PAGE and HPLC

 
Biological Activity:
The activity was tested by the ability of immobilized recombinant human L-Selectin to bind Human CD34 

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Human L-Selectin (CD62L) is lyophilized from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Storage:
Recombinant L-Selectin  can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

L-Selectin

L-selectin mediates lymphocyte binding to high endothelial venules of peripheral lymph nodes and leukocyte interactions with vascular endothelial cells during immune and inflammatory responses. L- selectin is constitutively expressed by most leukocytes, whereas the other members of the selectin family, P- and E- selectin, are expressed by activated vascular endothelium. In addition to mediating leukocyte/endothelial cell interactions, L-selectin can also mediate intercellular interactions between leukocytes. Neutrophil adherence to cultured endothelial cells supports the continued rolling of newly arriving neutrophils through L-selectin-dependent leukocyte-leukocyte interactions

Related Publications:
tweak inhibits traf2-mediated CD40 signaling by destabilization of CD40 signaling complexes
J. Immunol., Sep 2013; 191: 2308 - 2318.
a phase i study of an agonist CD40 monoclonal antibody (cp-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma
Clin. Cancer Res., Aug 2013; 10.1158/1078-0432.CCR-13-1320.
inhibition of cd8+ t cell–derived CD40 signals is necessary but not sufficient for foxp3+ induced regulatory t cell generation in vivo
J. Immunol., Aug 2013; 191: 1957 - 1964.
modulation of regulatory t cell function by monocyte-derived dendritic cells matured through electroporation with mrna encoding CD40 ligand, constitutively active tlr4, and cd70
J. Immunol., Aug 2013; 191: 1976 - 1983.
effects of CD40 ligation combined with chemotherapy drugs on human breast cancer cell lines
Journal of International Medical Research, Aug 2013; 10.1177/0300060513490084.




by class:
Cytokines
Chemokines
Growth factors
CD markers
Viral Antigens
Other
by species:
Human
mouse
Rat
Antibodies:
Purified Polyclonal
Related Products:
product_icon_8.jpg Mouse L-Selectin (CD62L) Recombinant
product_icon_8.jpg Human L-Selectin (CD62L) Recombinant
 
 
 
Item name Size Quantity Price(USD) Remove
checkout
Cart Total $