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Rat CD40 (TNFRSF5) Recombinant


accession:  Q9JKE0
   Size A     20ug   $ 160
   Size B      100ug  $430
   Size C      500ug  $ 1650
Domain  : 
Gene  :  CD40
Catalog no. :  RKQ9JKE0


Optimized DNA sequence  encoding  extracellular domain of Rat CD40 including a C-terminal His tag was expressed in HEK293 cells.

Molecular weight:

Recombinant CD40  is a  protein consisting of 185 amino acid residue subunits,  due to glycosylation migrates as an approximately 30kDa protein on SDS-PAGE.

>97%, as determined by SDS-PAGE and HPLC

Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Recombinant Rat CD40  is lyophilized from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

Recombinant CD40 can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.



The CD40 molecule is a 45- 50-kDa type I phosphorylated glycoprotein that belongs to the tumor necrosis factor receptor superfamily and was initially considered to be a growth factor receptor on B cells. The interaction of CD40 with its natural ligand, CD154, is a crucial step in T cell-dependent B cell activation and differentiation. The cellular events triggered in CD40-positive cells following CD40/CD154 interactions are not restricted to B cells only but can also be triggered in dendritic cells, monocytes, epithelial cells, endothelial cells, and fibroblasts. Thus, CD40 ligation mediates a broad variety of immune and inflammatory responses .

Related Publications:
tweak inhibits traf2-mediated CD40 signaling by destabilization of CD40 signaling complexes
J. Immunol., Sep 2013; 191: 2308 - 2318.
a phase i study of an agonist CD40 monoclonal antibody (cp-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma
Clin. Cancer Res., Aug 2013; 10.1158/1078-0432.CCR-13-1320.
inhibition of cd8+ t cell–derived CD40 signals is necessary but not sufficient for foxp3+ induced regulatory t cell generation in vivo
J. Immunol., Aug 2013; 191: 1957 - 1964.
modulation of regulatory t cell function by monocyte-derived dendritic cells matured through electroporation with mrna encoding CD40 ligand, constitutively active tlr4, and cd70
J. Immunol., Aug 2013; 191: 1976 - 1983.
effects of CD40 ligation combined with chemotherapy drugs on human breast cancer cell lines
Journal of International Medical Research, Aug 2013; 10.1177/0300060513490084.

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Growth factors
CD markers
Viral Antigens
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Purified Polyclonal
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