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Human CD27 (TNFRSF7) Recombinant

CD27

accession:  P26842
   Size A     50ug   $ 160
   Size B      200ug  $430
   Size C      1000ug  $ 1950
Domain  : 
Gene  :  CD27
Catalog no. :  RKP26842

 

Source:
Optimized DNA sequence  encoding  extracellular domain of Human CD27 including a C-terminal His tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant CD27  is a  protein consisting of 185 amino acid residue subunits,  due to glycosylation migrates as an approximately 27kDa protein on SDS-PAGE.


 
Purity:
>97%, as determined by SDS-PAGE and HPLC

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant human CD27  is lyophilized from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Storage:
Recombinant CD27 can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CD27

CD27 is a 120kDa type I transmembrane phosphoglycoprotein composed of disulfide-linked 55kDa monomers and belongs to the TNF receptor family. CD27 is expressed on medullary thymocytes (1, 20), on the surface of 75% of human peripheral blood T cells (equally distributed between CD4+ and CD8+ subsets) (1, 2), on a subpopulation of B cells, and on NK cells. The activation of human T cells via the TCR-CD3 complex leads to expression of CD27, which peaks after 3 to 4 days and then gradually decreases after prolonged activation.

Related Publications:
cd70 is downregulated by interaction with CD27
J. Immunol., Sep 2013; 191: 2282 - 2289.
determination of the attp and attb sites of phage CD27 from clostridium difficile nctc 12727
J. Med. Microbiol., Sep 2013; 62: 1439 - 1443.
cd8+ t cells produce the chemokine cxcl10 in response to CD27/cd70 costimulation to promote generation of the cd8+ effector t cell pool
J. Immunol., Aug 2013; 10.4049/jimmunol.1202222.
the human fetal lymphocyte lineage: identification by CD27 and lin28b expression in b-cell progenitors
J. Leukoc. Biol., Jul 2013; 10.1189/jlb.011304810.1189/jlb.0113048.
osteoclast precursors in murine bone marrow express CD27 and are impeded in osteoclast development by cd70 on activated immune cells
PNAS, Jul 2013; 110: 12385 - 12390.




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Antibodies:
Purified Polyclonal
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