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Human CD7 Recombinant

CD7

accession:  P09564
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  : 
Gene  :  CD7
Catalog no. :  RKP09564

 

Source:
Optimized DNA sequence  encoding  extracellular domain of Human CD7 including an C-terminal His tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant CD7  is a  protein consisting of 165 amino acid residue subunits,  due to glycosylation migrates as an approximately 40kDa protein on SDS-PAGE.


 
Purity:
>97%, as determined by SDS-PAGE and HPLC

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant human CD7  is lyophilized from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Storage:
Recombinant CD7 can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CD7

CD7 is a 40-kDa member of the Ig gene superfamily that is expressed in T and NK cells. CD7 signals through phosphatidylinositol 3- kinase, induces TCRγδ and NK cell IL-2, TNF-α, and IFN-γ production, and up-regulates cell adhesion molecule expression. Recent work has shown that the natural ligand for CD7 is a secreted molecule of epithelial, polymorphonuclear, and macrophage lineage cells called K-12 or SECTM-1 .

Related Publications:
functionally distinct subsets of human nk cells and monocyte/dc-like cells identified by coexpression of cd56, CD7, and cd4
Blood, Nov 2009; 114: 4823 - 4831.
aberrant expression of CD7 in myeloblasts is highly associated with de novo acute myeloid leukemias with flt3/itd mutation
Am J Clin Pathol, Apr 2008; 129: 624 - 629.
human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7– lympho-myeloid thymic progenitors
Blood, Feb 2008; 111: 1318 - 1326.
frequent CD7 antigen loss in aggressive natural killer-cell leukemia can be a useful diagnostic marker.
Blood (ASH Annual Meeting Abstracts), Nov 2007; 110: 2400.
co-operativity between antibody-dependent cellular cytotoxicity (adcc) and immunotoxin-mediated killing of human t-all cells in a scid mouse model: simultaneous delivery of saporin via CD7 and adcc via cd38 is no better than the simultaneous delivery of each against only CD7.
Blood (ASH Annual Meeting Abstracts), Nov 2006; 108: 4517.




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Antibodies:
Purified Polyclonal
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