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Rat CD2 (LFA-2) Recombinant


accession:  P08921
   Size A     5ug   $ 160
   Size B      20ug  $480
   Size C      100ug  $ 1950
Domain  : 
Gene  :  CD2
Catalog no. :  RKP08921


Optimized DNA sequence  encoding  extracellular domain of Rat CD2 (LFA-2) including an IgG1 Fc C-terminal tag was expressed in HEK293 cells.

Molecular weight:

Recombinant CD2 is a  homodimer protein consisting of 420 amino acid residue subunits,  due to glycosylation migrates as an approximately 60kDa protein on reduced conditions on SDS-PAGE.

>97%, as determined by SDS-PAGE and HPLC

Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Recombinant Rat CD2  is lyophilized from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

Recombinant Rat CD2 can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.



The CD2 molecule, also known as the sheep erythrocyte (E) rosette receptor, is a 50 kDa transmembrane glycoprotein and has a central role in T lymphocyte function. In humans, CD2 is expressed on all mature T lymphocytes, 95% of thymocytes and the majority of NK cells. The CD2 molecule functions as either an adhesion or a co- stimulation molecule. The interaction between the CD2 molecule and its ligand CD58 (LFA-3), which is considered to be the homolog of the sheep E rosette antigen, mediates adhesion between T cells and antigen- presenting cells, thereby enhancing antigen recognition via the CD3-T1 antigen-MHC receptor. The CD2 molecule can also be the target for an activating signal and T cell activation can be induced in the absence of accessory cells by co-stimulation with anti- CD2 and anti-CD3 mAb.

Related Publications:
high levels of CD2 expression identify hiv-1 latently infected resting memory cd4+ t cells in virally suppressed subjects
J. Virol., Aug 2013; 87: 9148 - 9158.
porcine t lymphocytes can be categorized into two functionally and developmentally distinct subsets according to expression of CD2 and level of tcr
J. Immunol., Mar 2013; 190: 2111 - 2120.
CD2+ block and permeation of cav3.1 (α1g) t-type calcium channels: candidate mechanism for CD2+ influx
Mol. Pharmacol., Dec 2012; 82: 1183 - 1193.
a pilot study of efficacy of lactobacillus CD2 lozenges in preventing high-dose chemotherapy induced oral mucositis in patients undergoing haematopoietic stem cell transplantation
Blood (ASH Annual Meeting Abstracts), Nov 2012; 120: 4500.
874 skewing of sag mediated therapy for a predominant th1 during visceral leishmaniasis on triggering CD2 epitope
Arch. Dis. Child., Oct 2012; 97: A251.

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Growth factors
CD markers
Viral Antigens
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Purified Polyclonal
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