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Human CD2 Recombinant

CD2

accession:  P06729
   Size A     10ug   $ 160
   Size B      50ug  $680
   Size C      200ug  $ 1950
Domain  : 
Gene  :  CD2
Catalog no. :  RKP06729

 

Source:
Optimized DNA sequence  encoding  extracellular domain of Human CD2 (SRBC) including an C-terminal His tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant CD2 (SRBC) is a  protein consisting of 195 amino acid residue subunits,  due to glycosylation migrates as an approximately 40kDa protein on SDS-PAGE.


 
Purity:
>97%, as determined by SDS-PAGE and HPLC

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant human CD2  is lyophilized from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Storage:
Recombinant CD2 can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CD2

The CD2 molecule, also known as the sheep erythrocyte (E) rosette receptor, is a 50 kDa transmembrane glycoprotein and has a central role in T lymphocyte function. In humans, CD2 is expressed on all mature T lymphocytes, 95% of thymocytes and the majority of NK cells. The CD2 molecule functions as either an adhesion or a co- stimulation molecule. The interaction between the CD2 molecule and its ligand CD58 (LFA-3), which is considered to be the homolog of the sheep E rosette antigen, mediates adhesion between T cells and antigen- presenting cells, thereby enhancing antigen recognition via the CD3-T1 antigen-MHC receptor. The CD2 molecule can also be the target for an activating signal and T cell activation can be induced in the absence of accessory cells by co-stimulation with anti- CD2 and anti-CD3 mAb.

Related Publications:
high levels of CD2 expression identify hiv-1 latently infected resting memory cd4+ t cells in virally suppressed subjects
J. Virol., Aug 2013; 87: 9148 - 9158.
porcine t lymphocytes can be categorized into two functionally and developmentally distinct subsets according to expression of CD2 and level of tcr
J. Immunol., Mar 2013; 190: 2111 - 2120.
CD2+ block and permeation of cav3.1 (α1g) t-type calcium channels: candidate mechanism for CD2+ influx
Mol. Pharmacol., Dec 2012; 82: 1183 - 1193.
a pilot study of efficacy of lactobacillus CD2 lozenges in preventing high-dose chemotherapy induced oral mucositis in patients undergoing haematopoietic stem cell transplantation
Blood (ASH Annual Meeting Abstracts), Nov 2012; 120: 4500.
874 skewing of sag mediated therapy for a predominant th1 during visceral leishmaniasis on triggering CD2 epitope
Arch. Dis. Child., Oct 2012; 97: A251.




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Cytokines
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by species:
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mouse
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Antibodies:
Purified Polyclonal
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