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Human CD226 Recombinant (DNAM-1)


accession:  Q15762
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  :  Ig-like C2
Gene  :  CD226
Catalog no. :  RKQ15762
Optimized DNA sequence  encoding  extracellular domain of HumanCD226 (DNAM-1) including a C-terminal His tag was expressed in HEK293 cells.

Molecular weight:

Recombinant  DNAM-1 (CD226) is a  protein consisting of 235 amino acid residue subunits,  due to glycosylation migrates as an approximately 45 kDa protein on SDS-PAGE.

>97%, as determined by SDS-PAGE and HPLC

Biological Activity:
Recombinant Human CD226 activity was measured using Immobilized Human CD226 at 2 őľg/ml ability to bind biotinylated Human CD112 with a linear ranger of 0.06- 0.8 őľg/ml

Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/¬Ķg(1EU/¬Ķg).

Recombinant Human CD226 ¬†is lyophilized from 0.2 őľm filtered PBS solution, ¬†pH7.2 , ¬†5% Trehalose.

Recombinant Human DNAM1 (CD226) can be stored in working aliquots at 2¬į - 8¬į C for one month, or at -20¬įC to¬†-70¬įC¬†for twelve months.

Avoid repeated freeze/thaw cycles.

This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.



DNAX accessory molecule 1 (DNAM-1; CD226) is a transmembrane glycoprotein member of the immunoglobulin superfamily. In humans, it is constitutively expressed on a subset of B lymphocytes and on all T lymphocytes, NK cells, monocytes, and platelets . DNAM-1 interacts with lymphocyte functionĖ associated antigen 1 (LFA- 1), and this association is required for its functional activity on both NK and cytotoxic T cells. Ligands for DNAM-1 (DNAM- 1Ls) include Nectin-2 and poliovirus receptor (PVR), which belong to the Nectin/Nectin-like family of adhesion molecules. DNAM1Ls are often expressed by tumor cells and can activate or enhance tumor cell lysis in vitro. Recent studies have reported that they can also be expressed by monocytes, DCs, and phytohemagglutinin (PHA)Ėstimulated CD4+ T lymphocytes

Related Publications:
association between the CD226 rs763361 polymorphism and susceptibility to autoimmune diseases: a meta-analysis
Lupus, Dec 2012; 21: 1522 - 1530.
correlational study of CD226 gene single nucleotide polymorphism and dilated cardiomyopathy in the chinese han population
Heart, Oct 2012; 98: E73.
crystal structure of cell adhesion molecule nectin-2/cd112 and its binding to immune receptor dnam-1/CD226
J. Immunol., Jun 2012; 188: 5511 - 5520.
the tigit/CD226 axis regulates human t cell function
J. Immunol., Apr 2012; 188: 3869 - 3875.
intranodal interaction with dendritic cells dynamically regulates surface expression of the co-stimulatory receptor CD226 protein on murine t cells
J. Biol. Chem., Nov 2011; 286: 39153 - 39163.

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