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Mouse CD22 (Siglec2) Recombinant

CD22

accession:  Q61451
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  :  Ig-like C2
Gene  :  CD22
Catalog no. :  RKP35329
Source:
Optimized DNA sequence  encoding Human extracellular domain of Mouse CD22 (SIGLEC2)  ncluding an N-terminal His tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant CD22 is a  protein consisting of 700 amino acid residue subunits,  due to glycosylation migrates as an approximately 120kDa protein on SDS-PAGE.


 
Purity:
>97%, as determined by SDS-PAGE and HPLC

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Mouse SIGLEC-2 (CD22)  is lyophilized from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Storage:
Recombinant Mouse CD22can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CD22

CD22 is a 135kDa B lymphocyte specific glycoprotein and a member of the sialoadhesin family of molecules. The major function of CD22 is to regulate B cell responses, which is likely accomplished by recruiting key signaling molecules to the antigen receptor complex. Experiments in knockout mice have established the importance of CD22 in modulating B cell responses in augmenting antibody responses, expanding peritoneal B-1 cell populations, and in increasing the levels of circulating autoantibodies

Related Publications:
phase i study of inotuzumab ozogamicin (ino) combined with r-gdp for relapsed CD22+ b-cell non-hodgkin lymphoma (b-nhl).
ASCO Meeting Abstracts, May 2013; 31: 2574.
dcdt2980s, an anti-CD22-monomethyl auristatin e antibody-drug conjugate, is a potential treatment for non-hodgkins lymphoma
Mol. Cancer Ther., Apr 2013; 10.1158/1535-7163.MCT-12-1173.
CD22 is required for protection against west nile virus infection
J. Virol., Mar 2013; 87: 3361 - 3375.
anti-CD22–chimeric antigen receptors targeting b-cell precursor acute lymphoblastic leukemia
Blood, Feb 2013; 121: 1165 - 1174.
CD22-targeting epratuzumab down-regulates multiple bcr regulators on the surface of normal, lupus, and malignant b cells
Blood (ASH Annual Meeting Abstracts), Nov 2012; 120: 1357.




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Antibodies:
Purified Polyclonal
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