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Mouse IL-18R1 Fc tag Recombinant

IL-18R

accession:  Q61098
   Size A     50ug   $ 160
   Size B      200ug  $480
   Size C      1000ug  $ 1950
Domain  : 
Gene  :  IL18R1
Catalog no. :  RKQ610981

Source:
Optimized DNA sequence  encoding extracellular domain of Mouse  IL-18 receptor  including an C terminal IgG1 Fc  tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant mouse IL-18 receptor alpha is a homodimer protein consisting of two 555 amino acid residue subunits,  due to glycosylation migrates as an approximately 95kD protein under reducing  SDS-PAGE conditions.


 
Purity:
>98%, as determined by SDS-PAGE and HPLC
 
Biological Activity:
Measured by its ability to bind immobilized recombinant human IL-18 at a concentration range of 1-32ng/ml in a functional ELISA assay.
 
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Mouse Interleukin-18 receptor alpha  is supplied as lyophilized 0.2 μm filtered PBS solution,  pH7.2 .

              
Storage:
Recombinant IL-18 receptor alpha, as supplied, can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

IL-18 receptor

The IL-18R complex is composed of two known chains, IL-18 receptor α chain (IL-18Rα)and IL-18Rβ. IL-18Rα (IL-1R5) was originally described as IL-1 receptor-related protein (IL-1Rrp) because of its homology with the IL-1/Toll receptor family and is the extracellular binding domain of the IL-18R complex. IL- 18Rβ (also known as IL- 18RAcPL or IL-1R7) is the signal transducing chain of the IL-18R complex and is also a member of the IL-1R family. It has been widely believed that the IL-18Rα is not expressed on naive T cells, but is induced during differentiation of Th1, but not Th2, cells.

Related Publications:
the interaction between il-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria
J. Immunol., Aug 2011; 187: 1333 - 1346.
the natural soluble form of IL-18 receptor β exacerbates collagen-induced arthritis via modulation of t-cell immune responses
Ann Rheum Dis, Jan 2010; 69: 276 - 283.
il-18 is induced and IL-18 receptor plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation
J. Immunol., Feb 2007; 178: 1948 - 1959.
responses of il-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor
PNAS, Nov 2006; 103: 16852 - 16857.
blockade of IL-18 receptor signaling delays the onset of autoimmune disease in mrl-faslpr mice
J. Immunol., Oct 2004; 173: 5312 - 5318.




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Antibodies:
Purified Polyclonal
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