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Mouse CD66a Recombinant (CEACAM1)

CD66

accession:  P31809
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  :  Ig-like C2
Gene  :  CEACAM1
Catalog no. :  RKP31809

Source:
Optimized DNA sequence  encoding extracellular domain of mouse CD66a including a C-terminal 6His tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant mouse CD66a (CEACAM-1) is a monomer protein consisting of 405 amino acid residue subunits,  due to glycosylation migrates as an approximately 65-85 kDa protein on SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC
 
 

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant mouse CD66a (CEACAM-1)  is supplied as a 0.2 μm filtered PBS solution,  pH7.2 .

              
Storage:
Recombinant CD66a, as supplied, can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only. It may not be used for therapeutics or diagnostic purposes.

 

CD66a

CD66a is a member of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. However, CD66a combines structural features of the immunoglobulin superfamily with functional properties of cadherins.The mechanism(s) by which CD66a transmits signals.are unclear. However, CD66a is phosphorylated on its cytoplasmic domain, largely on tyrosine with a lower level of phosphoserine, in neutrophils and colon cancer cells. While at least eight isoforms of CD66a derived from differential splicing have been described, only those isoforms with a long cytoplasmic tail can be phosphorylated on tyrosine. In addition, associated protein tyrosine kinase and phosphatase activities may be involved in CD66a signaling.

Related Publications:
inhibition of t-cell activation by a ceacam1 (CD66a) peptide
Blood (ASH Annual Meeting Abstracts), Nov 2008; 112: 4917.
ceacam1 (CD66a) promotes human monocyte survival via a phosphatidylinositol 3-kinase- and akt-dependent pathway
J. Biol. Chem., Dec 2006; 281: 39179 - 39193.
neisseria gonorrhoeae kills carcinoembryonic antigen-related cellular adhesion molecule 1 (CD66a)-expressing human b cells and inhibits antibody production
Infect. Immun., Jul 2005; 73: 4171 - 4179.
significance of the adhesion molecule ceacam1 (CD66a) as a prognostic factor for survival in patients with carcinomas of the lung
AACR Meeting Abstracts, Mar 2004; 2004: 1217.
CD66a interactions between human melanoma and nk cells: a novel class i mhc-independent inhibitory mechanism of cytotoxicity
J. Immunol., Mar 2002; 168: 2803 - 2810.




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Antibodies:
Purified Polyclonal
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