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Mouse IL2RA Recombinant (CD25)

IL-2R

accession:  P01590
   Size A     5ug   $ 160
   Size B      20ug  $480
   Size C      500ug  $ 4700
Domain  :  Extracellular
Gene  :  IL2RA
Catalog no. :  RKP01590

Source:
Optimized DNA sequence  encoding extracellular domain of mouse CD25  including a C-terminal polyHis tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant mouse CD25 is a monomer protein consisting of 223 amino acid residue subunits,  due to glycosylation migrates as an approximately 50 kDa protein on SDS-PAGE.


 
Purity:
>97%, as determined by SDS-PAGE and HPLC
 
 

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant CD25  is supplied as a 0.2 μm filtered PBS solution,  pH7.2 .

              
Storage:
Recombinant CD25, as supplied, can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CD25

This cell surface antigen is known also as TAC antigen . It is expressed on T-cells and B-cells following cell activation by antigens. An old designation for the murine counterpart is Ly43 . The rat antigen is OX39. CD25 is identical with IL2RA , which is the approved gene symbol. It is called also T- cell growth factor receptor (TCGFR)

Related Publications:
defects in il-2r signaling contribute to diminished maintenance of foxp3 expression in cd4+CD25+ regulatory t-cells of type 1 diabetic subjects
Diabetes, Feb 2010; 59: 407 - 415.
il-2/anti-il-2 antibody complexes show strong biological activity by avoiding interaction with il-2 receptor subunit CD25
PNAS, Jan 2010; 10.1073/pnas.0909384107.
functional characterization of alloreactive t cells identifies CD25 and cd71 as optimal targets for a clinically applicable allodepletion strategy
Blood, Jan 2010; 115: 396 - 407.
cd4+ t cell regulation of CD25 expression controls development of short-lived effector cd8+ t cells in primary and secondary responses
PNAS, Jan 2010; 107: 193 - 198.
cd4+CD25+ regulatory t cells resist a novel form of cd28- and fas-dependent p53-induced t cell apoptosis
J. Immunol., Jan 2010; 184: 94 - 104.




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by species:
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mouse
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Antibodies:
Purified Polyclonal
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