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Mouse IL-17RA (CD217) Recombinant

IL-17R

accession:  Q60943
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  : 
Gene  :  IL17RA
Catalog no. :  RKQ60943

Source:
Optimized DNA sequence  encoding extracellular domain of Mouse IL17R receptor  including a C terminal His  tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant Mouse IL17RA is a monomer protein consisting of 302 amino acid residue subunits,  due to glycosylation migrates as an approximately 55kD protein under reducing  SDS-PAGE conditions.


 
Purity:
>98%, as determined by SDS-PAGE and HPLC

 
Biological Activity:
Measured by its ability to bind immobilized recombinant human IL-17A at a concentration range of  1-6ng/ml  in a functional ELISA assay.

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Interleukin-17 receptor alpha  is supplied as lyophilized 0.2 μm filtered PBS solution,  pH7.2 .

              
Storage:
Recombinant IL-17 receptor alpha, as supplied, can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

IL-17RA

IL-17 is a potent regulator of the neutrophil response. Both IL-17A and IL-17F are capable of signaling through IL-17RA to induce granulopoietic factors such as G-CSF and stem cell factor which leads to expansion of neutrophil progenitors in the bone marrow and spleen, as well as expansion of mature neutrophils in peripheral blood. IL-17RA signaling up- regulates production of neutrophilic chemokines such as CXCL1 (KC), CXCL2, CXCL5, CXCL6, and CXCL8, which in turn regulate neutrophil emigration to mucosal sites . Due to this role in neutrophil expansion and recruitment, IL-17RA signaling is an important part of the host response to extracellular bacterial infections.To date, four additional receptors have been identified in the IL- 17R family based on sequence homology to IL-17R (IL- 17Rh1, IL-17RC, IL-17RD, and IL-17RE) and among them, IL- 17RC has been shown recently to physically associate with IL-17RA, suggesting that it may be a functional component in the IL-17R complex. Nevertheless, the final structure of the functional IL-17 receptor and the mechanisms of interactions with IL-17A remain unknown.

Related Publications:
cloning and characterisation of rainbow trout interleukin (il)-17a/f2 and IL-17RA: expression during infection and bioactivity of the recombinant il-17a/f2.
Infect. Immun., Nov 2012; 10.1128/IAI.00599-12.
the il-17a/IL-17RA axis plays a proatherogenic role via the regulation of aortic myeloid cell recruitment
Circ. Res., Mar 2012; 110: 675 - 687.
a cc' loop decoy peptide blocks the interaction between act1 and IL-17RA to attenuate il-17– and il-25–induced inflammation
Sci. Signal., Nov 2011; 4: ra72.
lack of IL-17RA signalling prevents autoimmune inflammation of the joint and give rise to a th2-like phenotype in collagen-induced arthritis
Ann Rheum Dis, Mar 2011; 70: A50 - A51.
il-17a- versus il-17f-induced intracellular signal transduction pathways and modulation by IL-17RA and il-17rc rna interference in rheumatoid synoviocytes
Ann Rheum Dis, Feb 2011; 70: 341 - 348.




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Antibodies:
Purified Polyclonal
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