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Mouse IL-7 receptor Recombinant (CD127)

IL-7R

accession:  P16872
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  :  Fibronectin
Gene  :  IL7RA
Catalog no. :  RKP16872

Source:
Optimized DNA sequence  encoding  extracellular domain of Mouse IL-7 receptor alpha  including a C-terminal His tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant Mouse IL-7 receptor alpha (IL-7R) is a  protein consisting of 226 amino acid residue subunits,  due to glycosylation migrates as an approximately 35 kDa protein on SDS-PAGE.


 
Purity:
>97%, as determined by SDS-PAGE and HPLC
 

 
 

Endotoxin:

Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Mouse IL-7R (CD127)  is lyophilized from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

              
Storage:
Recombinant Mouse IL-7 receptor can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

IL-7 receptor

IL-7R consists of a specific α-chain and a shared γc- chain and has low- and high- affinity forms . In response to IL-7, the IL-7R can cause distinct signaling through a number of signal-transducing factors, including the Janus tyrosine kinase/signal transducer and activator of transcription (STAT) signal transduction pathway . Depending on the system, IL- 7 signal transduction can also involve phosphatidylinositol-3 kinase, c-myc, nuclear factor of activated T cells, activated protein-1, p56lck, p59fyn,p53lyn, c-Jun N- terminal kinase, and p38 kinase.

Related Publications:
regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output
Blood, Oct 2009; 114: 3917 - 3927.
separate endocytic pathways regulate IL-5 receptor internalization and signaling
J. Leukoc. Biol., Aug 2008; 84: 499 - 509.
oct2 enhances antibody-secreting cell differentiation through regulation of IL-5 receptor chain expression on activated b cells
J. Exp. Med., Feb 2008; 205: 409 - 421.
nasal cholera toxin elicits il-5 and IL-5 receptor -chain expressing b-1a b cells for innate mucosal iga antibody responses
J. Immunol., May 2007; 178: 6058 - 6065.
jak kinases control IL-5 receptor ubiquitination, degradation, and internalization
J. Leukoc. Biol., Apr 2007; 81: 1137 - 1148.




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Antibodies:
Purified Polyclonal
Related Products:
product_icon_8.jpg Human IL-7 receptor Recombinant (CD127)
product_icon_8.jpg Mouse IL-7 receptor Recombinant (CD127)
 
 
 
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