Optimized DNA sequence encoding extracellular domain of Mouse IL-7 receptor alpha including a C-terminal His tag was expressed in HEK293 cells.
Recombinant Mouse IL-7 receptor alpha (IL-7R) is a protein consisting of 226 amino acid residue subunits, due to glycosylation migrates as an approximately 35 kDa protein on SDS-PAGE.
>97%, as determined by SDS-PAGE and HPLC
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).
Recombinant Mouse IL-7R (CD127) is lyophilized from 0.2 μm filtered PBS solution, pH7.2 , 5% Trehalose.
Recombinant Mouse IL-7 receptor can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.
Avoid repeated freeze/thaw cycles.
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.
IL-7R consists of a specific
α-chain and a shared γc-
chain and has low- and high-
affinity forms . In response
to IL-7, the IL-7R can cause
distinct signaling through a
number of signal-transducing
factors, including the Janus
transducer and activator of
transcription (STAT) signal
transduction pathway .
Depending on the system, IL-
7 signal transduction can
kinase, c-myc, nuclear
factor of activated T cells,
activated protein-1, p56lck,
p59fyn,p53lyn, c-Jun N-
terminal kinase, and p38
regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output
3917 - 3927.
separate endocytic pathways regulate IL-5 receptor internalization and signaling
J. Leukoc. Biol.,
499 - 509.
oct2 enhances antibody-secreting cell differentiation through regulation of IL-5 receptor chain expression on activated b cells
J. Exp. Med.,
409 - 421.
nasal cholera toxin elicits il-5 and IL-5 receptor -chain expressing b-1a b cells for innate mucosal iga antibody responses
6058 - 6065.
jak kinases control IL-5 receptor ubiquitination, degradation, and internalization
J. Leukoc. Biol.,
1137 - 1148.