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Rat IL-1 receptor type II Recombinant (CD121b)


accession:  P43303
   Size A     50ug   $ 160
   Size B      200ug  $550
   Size C      1000ug  $ 2150
Domain  :  Ig-like C2
Gene  :  IL1R2
Catalog no. :  RKP43303

Optimized DNA sequence  encoding Rat extracellular domain of Rat IL-1 receptor type II including a C-terminal His tag was expressed in HEK293 cells.

Molecular weight:

Recombinant rat IL-R2 (CD121b) is a  protein consisting of 353 amino acid residue subunits,  due to glycosylation migrates as an approximately 90 kDa protein on SDS-PAGE.

>97%, as determined by SDS-PAGE and HPLC



Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Recombinant Rat IL-1 receptor II (CD121b)  is lyophilized from 0.2 μm filtered PBS solution,  pH7.2 ,  5% Trehalose.

Recombinant Rat IL1R2 can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.


IL-1 receptor type II

Two distinct IL-lRs have been identified, termed type I and type II. The type I IL-lR is an 80-kDa glycoprotein found predominantly on T cells and fibroblasts, whereas the type II IL-lR is a 60- to 65-kDa molecule that is expressed on activated T cells, B cells, monocytes, and neutrophils. Evidence suggests that the type II IL-lR is not signal- transducing , and its function on the cell surface is unknown. The action of IL-1 is modulated not only by IL-lra but also by the release of a type II soluble IL-iR (sIL-lR). This 47-kDa soluble receptor is present in normal human plasma, serum, and synovial inflammatory exudate and in culture supernatants of activated peripheral blood mononuclear cells and neutrophils . sIL-lR is also released from the human B-cell Burkitt lymphoma cell line Raji, which expresses only type II IL-1R.

Related Publications:
pellino 2 is critical for toll-like receptor/interleukin-1 receptor (tlr/IL-1R)-mediated post-transcriptional control
J. Biol. Chem., Jul 2012; 287: 25686 - 25695.
role of toll interleukin-1 receptor (IL-1R) 8, a negative regulator of IL-1R/toll-like receptor signaling, in resistance to acute pseudomonas aeruginosa lung infection
Infect. Immun., Jan 2012; 80: 100 - 109.
IL-1R–associated kinase-1 mediates protein kinase c-induced il-1β production in monocytes
J. Immunol., Sep 2011; 187: 2632 - 2645.
effect of mitomycin c on IL-1R expression, il-1–related hepatocyte growth factor secretion and corneal epithelial cell migration
Invest. Ophthalmol. Vis. Sci., Mar 2010; 51: 1389 - 1396.
mycobacterium bovis bacillus calmette-guérin vaccination mobilizes innate myeloid-derived suppressor cells restraining in vivo t cell priming via IL-1R–dependent nitric oxide production
J. Immunol., Feb 2010; 184: 2038 - 2047.

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Purified Polyclonal
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product_icon_8.jpg Rat IL-1 receptor type II Recombinant (CD121b)
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