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Human CD113 Recombinant (Nectin-3)

CD113

accession:  Q9NQS3
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  :  Ig-like C2
Gene  :  PRR3
Catalog no. :  RKQ9NQS3

Source:
Optimized DNA sequence  encoding  extracellular domain of human CD113 (nectin-3) including a C-terminal 6His tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant CD113 (nectin-3) is a monomer protein consisting of 354 amino acid residue subunits, due to glycosylation migrates as an approximately 70 kDa protein on SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC

 

 
Biological Activity:

The activity of Recombinant human CD113 was measured in a functional ELISA assay, immobilized recombinant human CD113 at 1μg/ml ( 100μl/well ) can bind biotinylated Nectin-1 with a linear range of 6 - 800 μg/ml

Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant CD113 is supplied as a 0.2 μm filtered PBS solution, pH7.2.

              
Storage:
Recombinant CD113, as supplied, can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

Nectin-3

Nectins are a small family of Ca++independent immunoglobulin (Ig)like cell adhesion molecules (CAMs) that control cell adhesion, proliferation, and migration.Nectin2 is a 60 or 65 kDa type I TM glycoprotein that is found on a variety of cell types. Nectin2 is known to bind the pseudorabies virus, and herpes simplex virus2 (HSV2), but not HSV1. It does not bind poliovirus. As a cell adhesion molecule, Nectin2 will form cishomodimers , followed by transdimers

Related Publications:
inhibition of cell movement and proliferation by cell–cell contact-induced interaction of necl-5 with Nectin-3
J. Cell Biol., Oct 2005; 171: 165 - 173.
roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development
Development, Apr 2005; 132: 1525 - 1537.
Nectin-3 suppresses the invasive nature of human prostate cancer cells
AACR Meeting Abstracts, Apr 2005; 2005: 223.
nectin-like molecule-5/tage4 enhances cell migration in an integrin-dependent, Nectin-3-independent manner
J. Biol. Chem., Apr 2004; 279: 18015 - 18025.
recruitment of Nectin-3 to cell-cell junctions through trans-heterophilic interaction with cd155, a vitronectin and poliovirus receptor that localizes to v3 integrin-containing membrane microdomains
J. Biol. Chem., Aug 2003; 278: 31251 - 31260.




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Antibodies:
Purified Polyclonal
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