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Mouse LIFR Recombinant (CD118)

LIF-R

accession:  P42702
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  :  Ig-like C2
Gene  :  LIFR
Catalog no. :  RKP42703

Source:
Optimized DNA sequence  encoding  extracellular domain of mouse CD118 (LIFR) including a C-terminal 6His tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant CD118 (LIF receptor) is a monomer protein consisting of 796 amino acid residue subunits,  due to glycosylation migrates as an approximately 110 kDa protein on SDS-PAGE.


 
Purity:
>90%, as determined by SDS-PAGE and HPLC

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant mouse CD118 (LIFR) is supplied as a 0.2 μm filtered PBS solution,  pH7.2 .

              
Storage:
Recombinant mouse CD118, as supplied, can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

LIFR

LIF acts on its target cells via the activation of the LIF-receptor (LIFR) complex. The LIFR complex requires heterodimerisation of the two low affinity components LIFR and glycoprotein 130 (gp130), where combination transforms a low-affinity binding complex into a high- affinity binding site. Activation of the LIFR complex can trigger several signal transduction paIn LIF-induced heterodimerization with the LIFR, only the CBM of gp130 contacts LIF . The LIFR contributes mainly with its Ig-like domain to LIF binding .

Related Publications:
exercise rescued chronic kidney disease by attenuating cardiac hypertrophy through the cardiotrophin-1 LIFR/gp 130 jak/stat3 pathway
European Journal of Cardiovascular Prevention & Rehabilitation, Oct 2012; 10.1177/2047487312462827.
role of LIFR-gp130 activation in endogenous neuroprotection of retinal photoreceptors
Invest. Ophthalmol. Vis. Sci., May 2007; 48: 614.
dimerization of the cytokine receptors gp130 and LIFR analysed in single cells
J. Cell Sci., Nov 2005; 118: 5129 - 5140.
the developmental expression of vasoactive intestinal peptide (vip) in cholinergic sympathetic neurons depends on cytokines signaling through LIFRß-containing receptors
Development, Mar 2002; 129: 1387 - 1396.
preimplantation embryology: expression of leukaemia inhibitory factor receptor subunits LIFRß and gp 130 in human oocytes and preimplantation embryos
Mol. Hum. Reprod., May 1996; 2: 355 - 360.




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Antibodies:
Purified Polyclonal
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product_icon_8.jpg Human LIFR Recombinant (CD118)
product_icon_8.jpg Mouse LIFR Recombinant (CD118)
 
 
 
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