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Mouse SR-PSOX (CXCL16) Recombinant

CXCL16

accession:  Q8BSU2
   Size A     5ug   $ 70
   Size B      25ug  $160
   Size C      1mg  $ 2700
Domain  : 
Gene  :  CXCL16
Catalog no. :  RKQ8BSU2
Source:
Optimized DNA sequence encoding mouse SR-PSOX (CXCL16) mature chain was expressed in Escherichia Coli.

 
Molecular weight:

mouse CXCL16 , generated by the proteolytic removal of the signal peptide
and propeptide and has a calculated molecular mass of approximately 20kDa.

Recombinant mouse CXCL16 is a disulfide-linked monomeric protein consisting of 84 amino acid residue subunits and migrates as an approximately 9.5 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE.


 
Purity:
>98%, as determined by SDS-PAGE and HPLC

 
Biological Activity:
Determined by its ability to chemoattract mouse lymphocytes using a concentration range of 2.0-40.0 ng/ml.

 
Protein Sequence:
        10         20         30         40         50         60 
MRRGFGPLSL AFFLFLLALL TLPGDGNQGS VAGSCSCDRT ISSGTQIPQG TLDHIRKYLK 

        70         80         90        100        110        120 
AFHRCPFFIR FQLQSKSVCG GSQDQWVREL VDCFERKECG TGHGKSFHHQ KHLPQASTQT 

       130        140        150        160        170        180 
PEAAEGTPSD TSTPAHSQST QHSTLPSGAL SLNKEHTQPW EMTTLPSGYG LEARPEAEAN

       190        200        210        220        230        240 
 EKQQDDRQQE APGAGASTPA WVPVLSLLAI VFFLTAAMAY VLCNRRATQQ NSAGLQLWYT


PVEPRP 
(*)Complete precursor sequence shown, expressed chain highlighted
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant CXCL16 was lyophilized from a 0.2 μm filtered 20mM PB,100mM NaCl solution pH 7.5.

 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
The lyophilized protein is stable for at least 2 years from date of receipt at -20° C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:
This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CXCL16

CXCL16, a newly discovered CXC chemokine, exists both in a transmembrane and a soluble form. Membrane-bound CXCL16 is expressed by antigen-presenting cells such as monocytes, macrophages, B cells, and dendritic cells in the T- cell zone of lymph nodes. Soluble CXCL16 can be generated by constitutive cleavage from the cell membrane and further enhanced by cell stimulation with phorbol esters. Soluble CXCL16 has been shown to induce chemotaxis of Th1, Tc1, and natural killer T cells, which express the functional CXCR6 receptor. CXCL16 has also been reported as a novel angiogenic factor for human umbilical vein endothelial cells. Moreover, CXCL16 cDNA was shown to be identical to a novel scavenger receptor that binds phosphatidylserine and oxidized lipoprotein . Recently, expression of CXCL16 and/or CXCR6 was shown in nasopharyngeal carcinomas, gliomas, and rectal cancer. Through a cytokine antibody array, we reported that CXCL16 protein production was increased in aggressive prostate cancer cells compared with the less aggressive prostate cancer cells or benign prostate cells.

Related Publications:
eryptotic red blood cell adhesion to vascular endothelium: CXCL16/sr-psox, a pathophysiological amplifier
Am J Physiol Cell Physiol, Dec 2011; 10.1152/ajpcell.00453.2011.
dynamic adhesion of eryptotic erythrocytes to endothelial cells via CXCL16/sr-psox
Am J Physiol Cell Physiol, Dec 2011; 10.1152/ajpcell.00340.2011.
sr-psox/CXCL16 plays a critical role in the progression of colonic inflammation
Gut, Nov 2011; 60: 1494 - 1505.
CXCL16 recruits bone marrow-derived fibroblast precursors in renal fibrosis
J. Am. Soc. Nephrol., Oct 2011; 22: 1876 - 1886.
the CXCL16 a181v mutation selectively inhibits monocyte adhesion to cxcr6 but is not associated with human coronary heart disease
Arterioscler Thromb Vasc Biol, Apr 2011; 31: 914 - 920.




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