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Mouse MEC (CCL28 ) Recombinant

MEC

Freeze transfer
accession:  Q9JIL2
   Size A     5ug   $ 70
   Size B      20ug  $160
   Size C      1mg  $ 2700
Domain  :  IL8
Gene  :  CCL28
Catalog no. :  RKQ9JIL2
Source:
Optimized DNA sequence encoding mouse CCL28 mature chain was expressed in Escherichia Coli.

 
Molecular weight:

Native mouse MEC/CCL28 has a calculated molecular mass of approximately 12 kDa. 

Recombinant CCL28 is a disulfide-linked homodimeric protein consisting of 111 amino acid residue subunits, and migrates as an approximately 12 kDa protein under non-reducing and reducing conditions in SDS-PAGE.


 
Purity:
>97%, as determined by SDS-PAGE and HPLC

 
Biological Activity:
Determined by the ability to chemoattract human lymphocytes using a concentration range of 2.0-10.0 ng/ml.

 
Protein Sequence:
        10         20         30         40         50         60 
MQQAGLTLMA VAVCVAFQTS EAILPMASSC CTEVSHHVSG RLLERVSSCS IQRADGDCDL 

        70         80         90        100        110        120 
AAVILHVKRR RICISPHNRT LKQWMRASEV KKNGRENVCS GKKQPSRKDR KGHTTRKHRT 

       130 
RGTHRHEASR 
(*)Complete precursor sequence shown, expressed chain highlighted
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant CCL-28 was lyophilized from PBS pH 7.4.

 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:
This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

 

CCL28

The mucosa-associated epithelial chemokine CCL28 (mucosa-associated epithelial chemokine) is a common mucosal chemokine which is constitutively expressed by epithelial cells in most mucosal sites. Both CCL28 and CCL25 have recently been shown to be essential for lymphocyte migration to gastrointestinal tissues. CCL28 attracts IgA ASC, but not IgG or IgM ASC, from both intestinal and extraintestinal mucosal tissue, while CCL25 preferentially attracts IgA ASC from the small intestine and its draining lymphoid tissues, as well as α4β7+ T cells.

Related Publications:
mucosa-associated epithelial chemokine/CCL28 expression in the uterus attracts ccr10+ iga plasma cells following mucosal vaccination via estrogen control
J. Immunol., Sep 2011; 187: 3044 - 3052.
CCL28 is increased in human helicobacter pylori-induced gastritis and mediates recruitment of gastric immunoglobulin a-secreting cells
Infect. Immun., Jul 2008; 76: 3304 - 3311.
ccl25 and CCL28 promote 4β7-integrin-dependent adhesion of lymphocytes to madcam-1 under shear flow
Am J Physiol Gastrointest Liver Physiol, May 2008; 294: G1257 - G1267.
epithelial inflammation is associated with CCL28 production and the recruitment of regulatory t cells expressing ccr10
J. Immunol., Jul 2006; 177: 593 - 603.
redundant role of chemokines ccl25/teck and CCL28/mec in iga+ plasmablast recruitment to the intestinal lamina propria after rotavirus infection
J. Immunol., May 2006; 176: 5749 - 5759.




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product_icon_8.jpg Human MEC (CCL28 ) Recombinant
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