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Mouse MDC (CCL22 )Recombinant

MDC

accession:  O88430
   Size A     5ug   $ 70
   Size B      20ug  $160
   Size C      1mg  $ 2700
Domain  :  IL8
Gene  :  CCL22
Catalog no. :  RKO88430
Source:
Optimized DNA sequence encoding Mouse MDC (CCL22) mature chain was expressed in Escherichia Coli.

 
Molecular weight:

Native Mouse MDC/CCL22 has a calculated molecular mass of approximately 8 kDa. 

Recombinant MDC is a disulfide-linked homodimeric protein consisting of 67 amino acid residue subunits, and migrates as an approximately 8 kDa protein under non-reducing and reducing conditions in SDS-PAGE.


 
Purity:
>97%, as determined by SDS-PAGE and HPLC

              

Protein Sequence:

        10         20         30         40         50         60 
MATLRVPLLV ALVLLAVAIQ TSDAGPYGAN VEDSICCQDY IRHPLPSRLV KEFFWTSKSC 

        70         80         90 
RKPGVVLITV KNRDICADPR QVWVKKLLHK LS 

(*)Complete precursor sequence shown, expressed chain highlighted
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Biological Activity:
Determined by its ability to chemoattract human T cells using a concentration range of 10.0-50.0 ng/ml.

 
Presentation:

Recombinant mouse CCL22 is presented as 0.2μm filtered PBS pH 7.5 .

 

Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months. 

Avoid repeated freeze/thaw cycles.

 
Usage:
This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

 

CCL22

CCL22 (monocyte-derived chemokine) was described initially as a constitutively produced, thymus-specific chemokine, implicated in the recruitment of T cells . One of the functions of CCL22 originally described was induction of migration of CCR4+ Th2 cells, but it has additionally been shown to regulate migration of Tregs. CCL22 has been implicated in a number of diseases, including allergen-induced lung inflammation, atopic dermatitis, and lymphoma. Similarly, a presumed role for CCR4+ cells has been suggested for endotoxic shock, rheumatoid arthritis, T cell lymphoma, and autoimmune diabetes

Related Publications:
lack of association with rheumatoid arthritis of selected polymorphisms in 4 candidate genes: cfh, cd209, Eotaxin-3, and mhc2ta
J Rheumatol, Aug 2009; 36: 1590 - 1595.
Eotaxin-3 is involved in churg–strauss syndrome – a serum marker closely correlating with disease activity
Rheumatology, Jun 2008; 47: 804 - 808.
dsrna enhances Eotaxin-3 production through interleukin-4 receptor upregulation in airway epithelial cells
Eur. Respir. J., Nov 2005; 26: 795 - 803.
chronic aeroallergen during infancy enhances Eotaxin-3 expression in airway epithelium and nerves
Am. J. Respir. Cell Mol. Biol., Jul 2005; 33: 1 - 8.
Eotaxin-3 and interleukin-5 pleural fluid levels are associated with pleural fluid eosinophilia in post-coronary artery bypass grafting pleural effusions
Chest, Jun 2005; 127: 2094 - 2100.




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product_icon_8.jpg Human MDC (CCL22 )Recombinant
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