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Mouse IL-2RG Recombinant (CD132)

IL-2R

accession:  P34902
   Size A     20ug   $ 220
   Size B      100ug  $490
   Size C      1000ug  $ 4700
Domain  : 
Gene  :  IL2RG
Catalog no. :  RKP34902
Source:
DNA sequence encoding extracellular domain of Human IL2RG (Common gamma chain)  to a C-terminal polyHis tag was expressed in HEK cells.

 
Molecular weight:

Recombinant Human Interleukin-2 receptor gamma (Common gamma chain)  is a monomer consisting of 242 amino acid residue , and migrates as an approximately 43 kDa protein under reducing conditions in SDS-PAGE.

 
Purity:
>97%, as determined by SDS-PAGE

 
 

Protein Sequence:

 

        10         20         30         40         50         60 
MLKLLLSPRS FLVLQLLLLR AGWSSKVLMS SANEDIKADL ILTSTAPEHL SAPTLPLPEV 

        70         80         90        100        110        120 
QCFVFNIEYM NCTWNSSSEP QATNLTLHYR YKVSDNNTFQ ECSHYLFSKE ITSGCQIQKE 

       130        140        150        160        170        180 
DIQLYQTFVV QLQDPQKPQR RAVQKLNLQN LVIPRAPENL TLSNLSESQL ELRWKSRHIK 

       190        200        210        220        230        240 
ERCLQYLVQY RSNRDRSWTE LIVNHEPRFS LPSVDELKRY TFRVRSRYNP ICGSSQQWSK 

       250        260        270        280        290        300 
WSQPVHWGSH TVEENPSLFA LEAVLIPVGT MGLIITLIFV YCWLERMPPI PPIKNLEDLV 

       310        320        330        340        350        360 
TEYQGNFSAW SGVSKGLTES LQPDYSERFC HVSEIPPKGG ALGEGPGGSP CSLHSPYWPP 


PCYSLKPEA 

 

 

(*)Complete precursor sequence shown, expressed chain highlighted
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant Human IL2RG  was lyophilized from a 0.2 μm filtered PBS solution pH 7.4.

 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
The lyophilized protein is stable for at least 2 years from date of receipt at -20° C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:
This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

Common gamma chain

Interleukin (IL)-2, IL-4, IL-7, IL-9 and IL-15 belong to a family of cytokines whose receptors share the common γ chain (γc). Despite some redundancy, these cytokines that signal through the γc (γccytokines) have essentially distinct and often critical effects in normal T-cell development, survival, proliferation and differentiation. Importantly, they have also been implicated, directly or indirectly, in T-cell leukemogenesis.

Related Publications:
il-21 is the primary Common gamma chain-binding cytokine required for human b-cell differentiation in vivo
Blood, Oct 2011; 10.1182/blood-2011-06-362533.
il-2r common -chain is epigenetically silenced by nucleophosphin–anaplastic lymphoma kinase (npm-alk) and acts as a tumor suppressor by targeting npm-alk
PNAS, Jul 2011; 108: 11977 - 11982.
a subpopulation of follicular lymphoma tumor infiltrating t cells shows suppressed Common gamma chain cytokine signaling.
Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 759.
common -chain-dependent signals confer selective survival of eosinophils in the murine small intestine
J. Immunol., Nov 2009; 183: 5600 - 5607.
cell cycle progression following naive t cell activation is independent of jak3/common -chain cytokine signals
J. Immunol., Oct 2009; 183: 4493 - 4501.




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