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Mouse IL-11 receptor alpha Recombinant

IL-11

accession:  Q64385
   Size A     100ug   $ 160
   Size B      500ug  $640
   Size C      1000ug  $ 1050
Domain  :  Extracellular
Gene  :  IL11RA
Catalog no. :  RKQ64385
Source:
DNA sequence encoding  extracellular domain of Mouse IL-11RA fused to a C-terminal polyHis tag was expressed in HEK cells.

 
Molecular weight:

Recombinant Mouse Interleukin-11RA  is a monomer consisting of 355 amino acid residue subunits, and migrates as an approximately 46 kDa protein under reducing conditions in SDS-PAGE.

 
Purity:
>85%, as determined by SDS-PAGE and HPLC

 
Biological Activity:
The activity was determined by its ability to bind mouse IL-6ST in functional ELISA .

 
Protein Sequence:

 

        10         20         30         40         50         60 
MSSSCSGLTR VLVAVATALV SSSSPCPQAW GPPGVQYGQP GRPVMLCCPG VSAGTPVSWF 

        70         80         90        100        110        120 
RDGDSRLLQG PDSGLGHRLV LAQVDSPDEG TYVCQTLDGV SGGMVTLKLG FPPARPEVSC 

       130        140        150        160        170        180 
QAVDYENFSC TWSPGQVSGL PTRYLTSYRK KTLPGAESQR ESPSTGPWPC PQDPLEASRC 

       190        200        210        220        230        240 
VVHGAEFWSE YRINVTEVNP LGASTCLLDV RLQSILRPDP PQGLRVESVP GYPRRLHASW 

       250        260        270        280        290        300 
TYPASWRRQP HFLLKFRLQY RPAQHPAWST VEPIGLEEVI TDAVAGLPHA VRVSARDFLD 

       310        320        330        340        350        360 
AGTWSAWSPE AWGTPSTGPL QDEIPDWSQG HGQQLEAVVA QEDSPAPARP SLQPDPRPLD 

       370        380        390        400        410        420 
HRDPLEQVAV LASLGIFSCL GLAVGALALG LWLRLRRSGK DGPQKPGLLA PMIPVEKLPG 

       430 
IPNLQRTPEN FS 

 

(*)Complete precursor sequence shown, expressed chain highlighted
 

Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant mouse Interleukin-11receptor alpha was lyophilized from a 0.2 μm filtered PBS solution pH 7.4.

 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
The lyophilized protein is stable for at least 2 years from date of receipt at -20° C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:
This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

IL-11 receptor alpha

Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells.

Related Publications:
il-11 receptor in the pathogenesis of il-13-induced inflammation and remodeling
J. Immunol., Feb 2005; 174: 2305 - 2313.
recombinant soluble interleukin-11 (il-11) receptor -chain can act as an il-11 antagonist
Blood, Dec 1997; 90: 4403 - 4412.




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product_icon_8.jpg Human Interleukin-11 Recombinant
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product_icon_8.jpg Human IL-11 receptor alpha Recombinant
product_icon_8.jpg Mouse IL-11 receptor alpha Recombinant
 
 
 
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