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Human Fibroblast Growth Factor 21 Recombinant

FGF-21

accession:  Q9NSA1
   Size A     5ug   $ 70
   Size B      20ug  $160
   Size C      1mg  $ 2700
Domain  :  HBGF/IL1
Gene  :  FGF21
Catalog no. :  RKQ9NSA1
Source:
Optimized DNA sequence encoding Human Fibroblast Growth Factor-21 mature chain was expressed in Escherichia Coli.

 
Molecular weight:

Native human FGF21 is generated by the proteolytic removal of the signal peptide
and propeptide, this molecule has a calculated molecular mass of approximately 20kDa.

Recombinant Fibroblast Growth Factor 21 is a disulfide-linked monomer protein consisting of 182 amino acid residue subunits, and migrates as an approximately 20kDa protein under non-reducing and reducing conditions in SDS-PAGE.


 
Purity:
>96%, as determined by SDS-PAGE and HPLC

 
Protein Sequence:
        10         20         30         40         50         60 
MDSDETGFEH SGLWVSVLAG LLLGACQAHP IPDSSPLLQF GGQVRQRYLY TDDAQQTEAH 

        70         80         90        100        110        120 
LEIREDGTVG GAADQSPESL LQLKALKPGV IQILGVKTSR FLCQRPDGAL YGSLHFDPEA 

       130        140        150        160        170        180 
CSFRELLLED GYNVYQSEAH GLPLHLPGNK SPHRDPAPRG PARFLPLPGL PPALPEPPGI 

       190        200        210 
LAPQPPDVGS SDPLSMVGPS QGRSPSYAS 
(*)Complete precursor sequence shown, expressed chain highlighted
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant FGF21 was lyophilized from 0.2 μm filtered PBS solution, pH 7.0 .

 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
The lyophilized protein is stable for at least 2 years from date of receipt at -20° C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:
This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

 

FGF-21



Related Publications:
diminished diet-induced hyperglycemia and dyslipidemia and enhanced expression of ppar and FGF-21 in mice with hepatic ablation of brain-derived neurotrophic factor
J. Endocrinol., Jan 2010; 10.1677/JOE-09-0405.
βklotho is required for fibroblast growth factor (fgf) 21 signaling through fgf receptor (fgfr) 1c and fgfr3c
Mol. Endocrinol., Apr 2008; 22: 1006 - 1014.




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