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Rat Stromal Cell-Derived Factor-1 beta Recombinant


accession:  Q9QZD1
   Size A     2ug   $ 70
   Size B      10ug  $160
   Size C      1mg  $ 2700
Domain  :  IL8
Gene  :  CXCL12
Catalog no. :  RKQ9QZD11
Optimized DNA sequence encoding Rat Stromal Cell-Derived Factor-1 beta mature chain was expressed in Escherichia Coli.

Molecular weight:

Native Rat SDF-1 beta, generated by the proteolytic removal of the signal peptide and propeptide,the molecule has a calculated molecular mass of approximately 8 kDa.

Recombinant Rat SDF-1 beta is a disulfide-linked monomer protein consisting of 73 amino acid residue subunits, migrates as an approximately 8 kDa protein under non-reducing and reducing conditions in SDS-PAGE.

>97%, as determined by SDS-PAGE and HPLC

Biological Activity:
Determined by its ability to chemoattract human monocytes using a concentration range of 5-80 ng/ml.

Protein Sequence:
        10         20         30         40         50         60 

        70         80         90
(*)Complete precursor sequence shown, expressed chain highlighted
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Rat SDF-1 beta was lyophilized from a 0.2 μm filtered PBS solution  pH 7.5.

A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

The lyophilized protein is stable for at least 2 years from date of receipt at -20° C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.




SDF-1-alpha and SDF-1-beta are small cytokines belonging to the CXC- Chemokines. SDF-1 is identical with a chemokine reported to function as a pre-B-cell growth factor in the presence of IL7 and isolated originally from a murine bone marrow stromal cell line.Human SDF-1-alpha and SDF-1-beta are encoded by a single gene and arise by alternative splicing. SDF-1 acts on lymphocytes and monocytes but not neutrophils in vitro and is a highly potent chemoattractant for mononuclear cells in vivo. In addition. SDF-1 also induces intracellular actin polymerization in lymphocytes. SDF acts as a chemoattractant for human hematopoietic progenitor cells expressing CD34 giving rise to mixed types of progenitors, and more primitive types. The chemotactic response is inhibited by pertussis toxin. Chemotaxis of CD34(+) cells in response to SDF is increased by IL3 in vitro. SDF has been shown also to induce a transient elevation of cytoplasmic calcium in these cells.

Related Publications:
bone marrow stem and progenitor cell contribution to neovasculogenesis is dependent on model system with SDF-1 as a permissive trigger
Blood, Aug 2009; 10.1182/blood-2009-03-211342.
glycosaminoglycan mimetics inhibit SDF-1/cxcl12-mediated migration and invasion of human hepatoma cells
Glycobiology, Aug 2009; 10.1093/glycob/cwp130.
inhibition of the SDF-1-cxcr4 axis by the cxcr4 antagonist amd3100 suppresses the migration of cultured cells from atl patients and murine lymphoblastoid cells from htlv-i tax transgenic mice
Blood, Aug 2009; 10.1182/blood-2008-11-189308.
the cxcl12 (SDF-1)/cxcr4 axis is essential for the development of renal vasculature
J. Am. Soc. Nephrol., Aug 2009; 20: 1714 - 1723.
haematopoietic stem cell migration to the ischemic damaged kidney is not altered by manipulating the SDF-1/cxcr4-axis
Nephrol. Dial. Transplant., Jul 2009; 24: 2082 - 2088.

by class:
Growth factors
CD markers
Viral Antigens
by species:
Purified Polyclonal
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