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Rabbit anti mouse IL18BP Polyclonal

IL-18

accession:  O95998
   Size A     100ug   $ 290
   Size B      200ug  $390
   Size C      500ug  $ 490
Clone  : 
Isotype  :  IgG
Catalog no. :  RPA95998
Source:
Optimized DNA sequence encoding Human Interleukin-18 Binding Protein (IL-18BP) mature chain fused to an C-terminal polyHis tag was expressed in HEK cells.

 
Molecular weight:
Native human IL-18BP, generated by the proteolytic removal of the signal peptide and propeptide,the molecule has a calculated molecular mass of approximately 19 kDa.

Recombinant Interleukin-18 Binding Protein is a disulfide-linked monomer protein consisting of 164 amino acid residue subunits fused to a  polyHis tag, migrates due to glycosylation as an approximately as a 45kDa protein under non-reducing and reducing conditions in SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC

 
Biological Activity:
The activity of recombinant Interleukin-18 Binding Protein was determined by the ability to bind IL-18 in functional ELISA.

 
Protein Sequence:
        10         20         30         40         50         60 
MTMRHNWTPD LSPLWVLLLC AHVVTLLVRA TPVSQTTTAA TASVRSTKDP CPSQPPVFPA 

        70         80         90        100        110        120 
AKQCPALEVT WPEVEVPLNG TLSLSCVACS RFPNFSILYW LGNGSFIEHL PGRLWEGSTS 

       130        140        150        160        170        180 
RERGSTGTQL CKALVLEQLT PALHSTNFSC VLVDPEQVVQ RHVVLAQLWA GLRATLPPTQ 

       190 
EALPSSHSSP QQQG 
(*)Complete precursor sequence shown, expressed chain highlighted
 

 

Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant IL-18BP is supplied as an 0.2 μm filtered PBS solution.

 
 
Storage:
Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:
This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

IL-18 binding protein

IL-18BP is a secreted protein that binds IL-18 with high affinity and prevents its interaction with the IL-18R. Different isoforms of IL-18BP have been demonstrated, four in human and two in the murine system, and biological activity is limited to particular isoforms.IL-18 binding protein (IL-18BP) is a constitutively expressed and secreted protein that resembles the extracellular domains of Ig-like receptors but has no transmembrane form.Because IL-18 is one of the early signals leading to IFN-gamma production by T- helper (Th) type-1 cells, blocking IL-18 activity by IL-18BP may be involved in down-modulation of the early phases of immune responses.

 




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Antibodies:
Purified Polyclonal
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