Cart contains    items
SEARCH

  |
  |  
  |  
  |  
  |  
  |  
 
Browse by molecule: [A]  [B]  [C]  [D]  [E]  [F]  [G]  [H]  [I]  [J]  [K]  [L]  [M]  [N]  [O]  [P]  [Q]  [R]  [S]  [T]  [U]  [V]  [W]  [X]  [Y]  [Z]  

Human CD112 Recombinant (PRR2)

CD112

accession:  Q92692
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  :  Ig-like C2
Gene  :  PRR2
Catalog no. :  RKQ92692

Source:
Optimized DNA sequence  encoding Human extracellular domain of human CD112 including a C-terminal 6His tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant CD112 is a monomer protein consisting of 335 amino acid residue subunits, due to glycosylation migrates as an approximately 48 kDa protein on SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC

 

 
Biological Activity:

The activity of Recombinant human CD112 was measured in a functional ELISA assay, immobilized recombinant human CD112 at 20 μg/ml ( 100μl/well ) can bind biotinylated DNAM1 with a linear range of 0.08 - 3 μg/ml

Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant CD112 is supplied as a 0.2 μm filtered PBS solution, pH7.2.

              
Storage:
Recombinant CD112, as supplied, can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CD112

Nectins are a small family of Ca++independent immunoglobulin (Ig)like cell adhesion molecules (CAMs) that control cell adhesion, proliferation, and migration.Nectin2 is a 60 or 65 kDa type I TM glycoprotein that is found on a variety of cell types. Nectin2 is known to bind the pseudorabies virus, and herpes simplex virus2 (HSV2), but not HSV1. It does not bind poliovirus. As a cell adhesion molecule, Nectin2 will form cishomodimers , followed by transdimers

Related Publications:
mast cell costimulation by cd226/CD112 (dnam-1/nectin-2): a novel interface in the allergic process
J. Biol. Chem., Sep 2006; 281: 27190 - 27196.
expression of the dnam-1 ligands, nectin-2 (CD112) and poliovirus receptor (cd155), on dendritic cells: relevance for natural killer-dendritic cell interaction
Blood, Mar 2006; 107: 2030 - 2036.
analysis of the receptor-ligand interactions in the natural killer–mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the poliovirus receptor (cd155) and nectin-2 (CD112)
Blood, Mar 2005; 105: 2066 - 2073.
functional characterization of dnam-1 (cd226) interaction with its ligands pvr (cd155) and nectin-2 (prr-2/CD112)
Int. Immunol., Apr 2004; 16: 533 - 538.




by class:
Cytokines
Chemokines
Growth factors
CD markers
Viral Antigens
Other
by species:
Human
mouse
Rat
Antibodies:
Purified Polyclonal
Related Products:
product_icon_7.jpg Rabbit anti Human CD112 (Nectin2) Polyclonal
product_icon_8.jpg Human CD112 Recombinant (PRR2)
product_icon_8.jpg Mouse CD112 Recombinant (PRR2)
 
 
 
Item name Size Quantity Price(USD) Remove
checkout
Cart Total $