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Human CD112 Recombinant (PRR2)


accession:  Q92692
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1950
Domain  :  Ig-like C2
Gene  :  PRR2
Catalog no. :  RKQ92692

Optimized DNA sequence  encoding Human extracellular domain of human CD112 including a C-terminal 6His tag was expressed in HEK293 cells.

Molecular weight:

Recombinant CD112 is a monomer protein consisting of 335 amino acid residue subunits, due to glycosylation migrates as an approximately 48 kDa protein on SDS-PAGE.

>95%, as determined by SDS-PAGE and HPLC


Biological Activity:

The activity of Recombinant human CD112 was measured in a functional ELISA assay, immobilized recombinant human CD112 at 20 μg/ml ( 100μl/well ) can bind biotinylated DNAM1 with a linear range of 0.08 - 3 μg/ml

Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Recombinant CD112 is supplied as a 0.2 μm filtered PBS solution, pH7.2.

Recombinant CD112, as supplied, can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.



Nectins are a small family of Ca++independent immunoglobulin (Ig)like cell adhesion molecules (CAMs) that control cell adhesion, proliferation, and migration.Nectin2 is a 60 or 65 kDa type I TM glycoprotein that is found on a variety of cell types. Nectin2 is known to bind the pseudorabies virus, and herpes simplex virus2 (HSV2), but not HSV1. It does not bind poliovirus. As a cell adhesion molecule, Nectin2 will form cishomodimers , followed by transdimers

Related Publications:
mast cell costimulation by cd226/CD112 (dnam-1/nectin-2): a novel interface in the allergic process
J. Biol. Chem., Sep 2006; 281: 27190 - 27196.
expression of the dnam-1 ligands, nectin-2 (CD112) and poliovirus receptor (cd155), on dendritic cells: relevance for natural killer-dendritic cell interaction
Blood, Mar 2006; 107: 2030 - 2036.
analysis of the receptor-ligand interactions in the natural killer–mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the poliovirus receptor (cd155) and nectin-2 (CD112)
Blood, Mar 2005; 105: 2066 - 2073.
functional characterization of dnam-1 (cd226) interaction with its ligands pvr (cd155) and nectin-2 (prr-2/CD112)
Int. Immunol., Apr 2004; 16: 533 - 538.

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Growth factors
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Purified Polyclonal
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