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Human IL-6 Receptor Recombinant (IL-6R)


accession:  P08887
   Size A     10ug   $ 160
   Size B      50ug  $550
   Size C      500ug  $ 2800
Domain  :  Ig-like C2
Gene  :  IL6R
Catalog no. :  RKP08887

Optimized DNA sequence  encoding  extracellular domain of human IL-6 receptor (CD126) including a C-terminal 6His tag was expressed in HEK293 cells.

Molecular weight:

Recombinant IL-6 receptor (CD126) is a monomer protein consisting of 357 amino acid residue subunits, due to glycosylation migrates as an approximately 60-65 kDa protein on SDS-PAGE.

>97%, as determined by SDS-PAGE and HPLC

Biological Activity:

Recombinant IL-6R (CD126) activity was determined by its ability to enhance the IL6 activity on M1 mouse myeloid leukemia cells. The ED50 for this effect is typically 20-80 ng/ml.

Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Recombinant Human Interleukin-6 receptor (CD126) is supplied as a 0.2 μm filtered PBS solution, pH7.2.

Recombinant  human IL-6R, as supplied, can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.


IL-6 receptor

The effects of IL-6 are mediated by a functional IL- 6 receptor (IL-6R), which consists in a heterodimer formed by an IL-6-binding α chain (IL-6Rα) and a signal- transducing subunit, gp130 or IL-6Rβ. Binding of IL-6 to the IL-6Rα induces homodimerization of two gp130 molecules, leading to intracellular signals.

Related Publications:
anti-inflammatory effect of IL-6 receptor blockade on experimental corneal alkali burn
Invest. Ophthalmol. Vis. Sci., Mar 2012; 53: 4206.
exposure-response relationship of tocilizumab, an anti–IL-6 receptor monoclonal antibody, in a large population of patients with rheumatoid arthritis
J. Clin. Pharmacol., Feb 2012; 10.1177/0091270012437585.
impact of IL-6 receptor inhibition on human memory b cells in vivo: impaired somatic hypermutation in preswitch memory b cells and modulation of mutational targeting in memory b cells
Ann Rheum Dis, Aug 2011; 70: 1507 - 1510.
species specificity of adam10 and adam17 proteins in interleukin-6 (il-6) trans-signaling and novel role of adam10 in inducible IL-6 receptor shedding
J. Biol. Chem., Apr 2011; 286: 14804 - 14811.
anti-IL-6 receptor antibody (tocilizumab): a b cell targeting therapy
Ann Rheum Dis, Mar 2011; 70: A57 - A58.

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Purified Polyclonal
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