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Human CD150 Recombinant (SLAM)

CD150

accession:  Q13291
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1650
Domain  :  Ig-like C2
Gene  :  SLAM
Catalog no. :  RKQ13291

Source:
Optimized DNA sequence  encoding Human extracellular domain of human SLAM (CD150) including a C-terminal 6His tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant SLAM(CD150) is a monomer protein consisting of 228 amino acid residue subunits,  due to glycosylation migrates as an approximately 45-50 kDa protein on SDS-PAGE.


 
Purity:
>97%, as determined by SDS-PAGE and HPLC

 
Biological Activity:
The actiity of recombinant SLAM (CD150) was measured by its ability to bind biotinylated recombinant human SH2D1A in a functional ELISA.

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant CD150 is supplied as a 0.2 μm filtered PBS solution,  pH7.2 .

              
Storage:
Recombinant SLAM (CD150), as supplied, can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CD150

The SLAM family of receptors is a group of type I transmembrane receptors that includes SLAM (CD150; SLAMF1), 2B4 (CD244; SLAMF4), Ly-9 (CD229; SLAMF3), natural killer, T- and B-cell antigen (NTB-A) or Ly108 (in the mouse) (SLAMF6), CD84 (SLAMF5), and CD2-like receptor activating cytotoxic cells (CRACC; CD319; and SLAMF7). SLAM-family receptors are broadly expressed in immune cells, and are not found in nonimmune cells. They possess an extracellular segment usually composed of two immunoglobulin (Ig)-like domains—one variable (V)- like domain and one constant 2 (C2)-like domain—in addition to a transmembrane region and a cytoplasmic domain bearing multiple tyrosine-based motifs

Related Publications:
signaling lymphocytic activation molecule (slam, CD150)-blind measles virus is attenuated and induces strong adaptive immune responses in rhesus monkeys
J. Virol., Jan 2010; 10.1128/JVI.02304-09.
measles virus infection of alveolar macrophages and dendritic cells precedes spread to lymphatic organs in transgenic mice expressing human signaling lymphocytic activation molecule (slam, CD150)
J. Virol., Dec 2009; 10.1128/JVI.01559-09.
human and rhesus macaque hematopoietic stem cells are not enriched in the CD150+cd48- slam population.
Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 3531.
dynamic interaction of the measles virus hemagglutinin with its receptor signaling lymphocytic activation molecule (slam, CD150)
J. Biol. Chem., Apr 2008; 283: 11763 - 11771.
CD150– side population cells represent a functionally distinct population of long-term hematopoietic stem cells
Blood, Feb 2008; 111: 2444 - 2451.




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Antibodies:
Purified Polyclonal
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product_icon_8.jpg Human CD150 Recombinant (SLAM)
 
 
 
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