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Human CD200 Recombinant (MOX1)

CD200

accession:  P41217
   Size A     20ug   $ 160
   Size B      100ug  $480
   Size C      500ug  $ 1650
Domain  :  Ig-like C2
Gene  :  MOX1
Catalog no. :  RKP41217

Source:
Optimized DNA sequence encoding Human extracellular domain of human CD200 including a C-terminal 6His tag was expressed in HEK293 cells.

 
Molecular weight:

Recombinant CD200 is a monomer protein consisting of 213 amino acid residue subunits,  due to glycosylation migrates as an approximately 40-45kDa protein on SDS-PAGE.


 
Purity:
>98%, as determined by SDS-PAGE and HPLC

 
Biological Activity:
The activity was tested by the ability of immobilized recombinant mouse CD200 (1ug/ml,100ul/well) to bind mouse CD200R1 with a linear range of 0.1-20 ng/ml

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant CD200 is supplied as a 0.2 μm filtered PBS solution,  pH7.2 .

              
Storage:
Recombinant CD200, as supplied, can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CD200

CD200 is a member of the immunoglobulin type 1 superfamily that is highly expressed in the central nervous system, dendritic cells, and lymphocytes. CD200 is functionally involved in an immunosuppressive signaling pathway via interaction with its receptor, CD200R, with downstream effects of macrophage inhibition, induction of regulatory T cells, and inhibition of tumor-specific T cells. In addition to being expressed in normal tissues, CD200 has also been demonstrated in solid tumors5 and hematologic malignancies, such as acute leukemias, chronic lymphocytic leukemia/small lymphocytic lymphoma, hairy cell leukemia, mediastinal large B-cell lymphoma, classic Hodgkin lymphoma, and angioimmunoblastic T-cell lymphoma. In addition, neoplastic plasma cells frequently upregulate CD200 expression, as demonstrated by the large proportion of CD200+ plasma cell myeloma (PCM) cases (approximately 70%) found on gene expression profiling and flow cytometry. In contrast, normal plasma cells are CD200.

Related Publications:
CD200 is preferentially expressed in cd138 dim multiple myeloma cells: implications for a myeloma stem cell subpopulation with potential immune-resistance.
Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 4877.
essential roles for dok2 and rasgap in CD200 receptor-mediated regulation of human myeloid cells
J. Immunol., Oct 2009; 183: 4879 - 4886.
lack of CD200 enhances pathological t cell responses during influenza infection
J. Immunol., Aug 2009; 183: 1990 - 1996.
expression of a CD200 transgene is necessary for induction but not maintenance of tolerance to cardiac and skin allografts
J. Immunol., Aug 2009; 183: 1560 - 1568.
induction of CD200 signalling reduces inflammatory cell infiltration and inhibits laser-induced choroidal neovascularization
Invest. Ophthalmol. Vis. Sci., Apr 2009; 50: 3759.




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Antibodies:
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