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Monoclonal Mouse anti Human CD16

CD16

accession:  P08637
   Size A       $
   Size B      500ug  $400
   Size C      1mg  $ 600
Clone  :  RKCD16
Isotype  :  IgG2a
Catalog no. :  RMA08637
Applications:
  • Western blot: This monoclonal antibody has been tested in WB analysis of human CD16a,CD16b. A suitable range of concentrations of this antibody for WB detection is 0.5-2 µg/ml.
 
Source:
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with recombinant human CD16a.
 
Species reactivity:
Human
 
Purification:

The IgG fraction of the tissue culture supernatant was purified by Protein A affinity chromatography.

 
Presentation:
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml .
 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers
 
Storage:
The lyophilized antibody is stable for at least 1 year  from date of receipt at -20° C.
Upon reconstitution, this antibody can be stored in working aliquots at 2° - 8° C , or at -20° C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:

This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CD16

Human CD16 is encoded by two genes, FcγRIIIA and FcγRIIIB. FcγRIIIa is a transmembranous isoform of the receptor expressed on the surface of natural killer (NK) cells, macrophages, a subset of monocytes and of T cells in association with dimers of the γ-chain of FcεRI and/or ζ-chain of T-cell receptors. FcγRIIIb is a glycosylphosphatidylinositol -anchored isoform restricted to neutrophils. FcγRIII plays a significant role in the clearance of immune complexes, antibody- dependent cellular cytotoxicity of K/NK cells,phagocytosis and antigen presentation.

Related Publications:
affinity and kinetic analysis of fc receptor iiia (CD16a) binding to igg ligands
J. Biol. Chem., Mar 2007; 282: 6210 - 6221.
phagocytosis stimulates mobilization and shedding of intracellular CD16a in human monocytes and macrophages: inhibition by hiv-1 infection
J. Leukoc. Biol., Feb 2006; 79: 294 - 302.




by class:
Cytokines
Chemokines
Growth factors
CD markers
Viral Antigens
Other
by species:
Human
mouse
Rat
Antibodies:
Purified Polyclonal
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product_icon_8.jpg Human CD16b Recombinant (FcgR3b), Biotinylated
product_icon_17.jpg Monoclonal Mouse anti Human CD16
product_icon_8.jpg Human CD16a Recombinant (FcgR3a), Biotinylated
 
 
 
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