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Human CD38 Recombinant


accession:  P28907
   Size A     5ug   $ 160
   Size B      20ug  $480
   Size C      100ug  $ 1950
Domain  :  ADP ribosyl cyclase
Gene  :  CD38
Catalog no. :  RKP28907

Optimized DNA sequence  encoding Human extracellular domain of human CD38 including a C-terminal 6His tag was expressed in HEK293 cells.

Molecular weight:

Recombinant CD38 is a monomer protein consisting of 269 amino acid residue subunits,  due to glycosylation migrates as an approximately 45 kDa protein on SDS-PAGE.

>95%, as determined by SDS-PAGE and HPLC

Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Recombinant CD38  is supplied as a 0.2 μm filtered PBS solution,  pH7.2 .

Recombinant CD38, as supplied, can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to -70°C for twelve months.

Avoid repeated freeze/thaw cycles.

This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.



Human CD38 is a broadly expressed type II transmembrane glycoprotein of ~45 kDa in its monomeric form. This consists of a short intracytoplasmic (IC) tail, a transmembrane domain and a major extracellular domain (ECD) formed by 256 of the 300 constituent amino acids of the CD38 polypeptide.The CD38 ECD, where both receptor and enzymatic activities reside, harbours a 12 cysteine/6 disulfide signature common to the members of this family.

Related Publications:
the ac133+CD38–, but not the rhodamine-low, phenotype tracks ltc-ic and src function in human cord blood ex vivo expansion cultures
Blood, Jan 2010; 115: 257 - 260.
CD38-mediated ca2+ signaling contributes to angiotensin ii-induced activation of hepatic stellate cells: attenuation of hepatic fibrosis by CD38 ablation
J. Biol. Chem., Jan 2010; 285: 576 - 582.
CD38 induces homing of chronic lymphocytic leukemia cells to the lymphoid organs through a functional interplay with cxcr4.
Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 2328.
CD38 expression on cd34+ cells as a single flow cytometric parameter to distinguish myelodysplastic syndromes (mds) from non-clonal cytopenias.
Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 2783.
CD38 cd49d are physically and functionally associated in b-cell chronic lymphocytic leukemia cells.
Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 357.

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Purified Polyclonal
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