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Monoclonal Mouse anti Human CD42b(gpIb)

CD42

accession:  P07359
   Size A       $
   Size B      500ug  $400
   Size C      1mg  $ 600
Clone  :  RKCD42
Isotype  :  IgG1
Catalog no. :  RMA07359B
Applications:
  • Western blot: This monoclonal antibody has been tested in WB analysis of human CD42b . A suitable range of concentrations of this antibody for WB detection is 0.5-2 µg/ml.
 
Source:
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with recombinant E. coli-derived Human CD42b. 
 
Species reactivity:
Human
 
Purification:

The IgG fraction of the tissue culture supernatant was purified by Protein G affinity chromatography.

 
Presentation:
Lyophilized from sterile filtered solution at a concentration of 1mg/ml in citrate-phosphate buffer pH7.0, with 0.02%Proclin 300 as a preservative.
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).
 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers
 
Storage:
The lyophilized antibody is stable for at least 1 year  from date of receipt at -20° C.
Upon reconstitution, this antibody can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:

This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CD42b

CD42b(gpIb) is part of a Glycoprotein Ib-IX-V (GPIb- IX-V) complex, the receptor for von Willebrand factor (VWF). This receptor plays a critical role in thrombus formation in damaged blood vessels under high shear. ssociation between VWF and GPIb-IX-V allows the adhesion protein to tether (or capture) rapidly flowing platelets into the developing thrombus. A fast off-rate of dissociation, however, means that platelets rapidly detach from VWF, unless integrins such as IIb3 or 21 are activated by intracellular signals, thereby enabling them to bind their ligands and mediate stable adhesion and thrombus growth.

Related Publications:
biclonal (cd34+ CD42b+) myeloblastic and megakaryoblastic transformation of chronic myeloproliferative/myelodysplastic disorders
Blood (ASH Annual Meeting Abstracts), Nov 2008; 112: 5242.




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Antibodies:
Purified Polyclonal
Related Products:
product_icon_17.jpg Monoclonal Mouse anti Human CD42b(gpIb)
 
 
 
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